Autoimmunity in vitiligo: Relationship with hla, gm and km polymorphisms

R. Lorini; G. Orecchia; M. Martinetti; J. M. Dugoujon; M. Cuccia

doi:10.3109/08916939209035163

Autoimmunity in vitiligo: Relationship with hla, gm and km polymorphisms

R. Lorini, G. Orecchia, M. Martinetti, J. M. Dugoujon, M. Cuccia

Research output: Contribution to journal › Article › peer-review

Abstract

Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71% in particular anti-parietal cells (26.6% antithyroglobulin (24.4% and antithyroid microsomal antibodies (43% One patient was also affected by Hashimoto's thyroiditis, 4 by Graves' disease and two others by nontoxic, multinodular goiter. No correlation was found between chronologic age and sex and the presence of autoantibodies, while an increased frequency of organ-specific autoantibodies was found with longer duration of vitiligo. HLA-A3 and Gm (3; 23; 5, 10, 11, 13, 14) phenotype frequencies were significantly increased in patients without autoantibodies (P

Original language	English
Pages (from-to)	255-260
Number of pages	6
Journal	Autoimmunity
Volume	11
Issue number	4
DOIs	https://doi.org/10.3109/08916939209035163
Publication status	Published - 1992

Keywords

Autoantibodies
HLA polymorphisms, Gm and Km allotypes
Vitiligo

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.3109/08916939209035163

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abstract = "Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71% in particular anti-parietal cells (26.6% antithyroglobulin (24.4% and antithyroid microsomal antibodies (43% One patient was also affected by Hashimoto's thyroiditis, 4 by Graves' disease and two others by nontoxic, multinodular goiter. No correlation was found between chronologic age and sex and the presence of autoantibodies, while an increased frequency of organ-specific autoantibodies was found with longer duration of vitiligo. HLA-A3 and Gm (3; 23; 5, 10, 11, 13, 14) phenotype frequencies were significantly increased in patients without autoantibodies (P",

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AU - Orecchia, G.

AU - Martinetti, M.

AU - Dugoujon, J. M.

AU - Cuccia, M.

PY - 1992

Y1 - 1992

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AB - Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71% in particular anti-parietal cells (26.6% antithyroglobulin (24.4% and antithyroid microsomal antibodies (43% One patient was also affected by Hashimoto's thyroiditis, 4 by Graves' disease and two others by nontoxic, multinodular goiter. No correlation was found between chronologic age and sex and the presence of autoantibodies, while an increased frequency of organ-specific autoantibodies was found with longer duration of vitiligo. HLA-A3 and Gm (3; 23; 5, 10, 11, 13, 14) phenotype frequencies were significantly increased in patients without autoantibodies (P

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Autoimmunity in vitiligo: Relationship with hla, gm and km polymorphisms

Abstract

Keywords

ASJC Scopus subject areas

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