Autofluorescence of orange pigment overlying small choroidal melanoma

Carol L. Shields; Carlos Bianciotto; Cesare Pirondini; Miguel A. Materin; Sarah A. Harmon; Jerry A. Shields

doi:10.1097/IAE.0b013e31814934ef

Autofluorescence of orange pigment overlying small choroidal melanoma

Carol L. Shields, Carlos Bianciotto, Cesare Pirondini, Miguel A. Materin, Sarah A. Harmon, Jerry A. Shields

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: To describe the autofluorescence features of orange pigment (intracellular lipofuscin) overlying small presumed choroidal melanomas. METHODS: The diagnostic testing results (fluorescein angiography, optical coherence tomography, and fundus autofluorescence imaging) for two patients with pigmented choroidal melanoma and two patients with nonpigmented choroidal melanoma were reviewed. RESULTS: Clinically, the intracellular lipofuscin pigment appeared brown overlying the nonpigmented melanoma (two cases) and orange overlying the pigmented melanoma (two cases). Fluorescein angiography demonstrated that the lipofuscin pigment displayed fluorescein blockage in all four cases. Optical coherence tomography revealed serous retinal detachment in all four cases. Fundus autofluorescence imaging showed discrete, bright hyperautofluorescence of the orange pigment separated by hypoautofluorescent voids. The melanoma was isoautofluorescent. CONCLUSIONS: Intracellular lipofuscin overlying small choroidal melanomas shows discrete and bright hyperautofluorescence. The brightness correlates directly with the clinically visible orange pigment.

Original language	English
Pages (from-to)	1107-1111
Number of pages	5
Journal	Retina
Volume	27
Issue number	8
DOIs	https://doi.org/10.1097/IAE.0b013e31814934ef
Publication status	Published - Oct 2007

Keywords

Autofluorescence
Choroidal melanoma
Eye tumor
Lipofuscin
Nonpigmented
Orange pigment
Pigmented

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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10.1097/IAE.0b013e31814934ef

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title = "Autofluorescence of orange pigment overlying small choroidal melanoma",

abstract = "PURPOSE: To describe the autofluorescence features of orange pigment (intracellular lipofuscin) overlying small presumed choroidal melanomas. METHODS: The diagnostic testing results (fluorescein angiography, optical coherence tomography, and fundus autofluorescence imaging) for two patients with pigmented choroidal melanoma and two patients with nonpigmented choroidal melanoma were reviewed. RESULTS: Clinically, the intracellular lipofuscin pigment appeared brown overlying the nonpigmented melanoma (two cases) and orange overlying the pigmented melanoma (two cases). Fluorescein angiography demonstrated that the lipofuscin pigment displayed fluorescein blockage in all four cases. Optical coherence tomography revealed serous retinal detachment in all four cases. Fundus autofluorescence imaging showed discrete, bright hyperautofluorescence of the orange pigment separated by hypoautofluorescent voids. The melanoma was isoautofluorescent. CONCLUSIONS: Intracellular lipofuscin overlying small choroidal melanomas shows discrete and bright hyperautofluorescence. The brightness correlates directly with the clinically visible orange pigment.",

keywords = "Autofluorescence, Choroidal melanoma, Eye tumor, Lipofuscin, Nonpigmented, Orange pigment, Pigmented",

author = "Shields, {Carol L.} and Carlos Bianciotto and Cesare Pirondini and Materin, {Miguel A.} and Harmon, {Sarah A.} and Shields, {Jerry A.}",

year = "2007",

month = oct,

doi = "10.1097/IAE.0b013e31814934ef",

language = "English",

volume = "27",

pages = "1107--1111",

journal = "Retina",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Autofluorescence of orange pigment overlying small choroidal melanoma

AU - Shields, Carol L.

AU - Bianciotto, Carlos

AU - Pirondini, Cesare

AU - Materin, Miguel A.

AU - Harmon, Sarah A.

AU - Shields, Jerry A.

PY - 2007/10

Y1 - 2007/10

N2 - PURPOSE: To describe the autofluorescence features of orange pigment (intracellular lipofuscin) overlying small presumed choroidal melanomas. METHODS: The diagnostic testing results (fluorescein angiography, optical coherence tomography, and fundus autofluorescence imaging) for two patients with pigmented choroidal melanoma and two patients with nonpigmented choroidal melanoma were reviewed. RESULTS: Clinically, the intracellular lipofuscin pigment appeared brown overlying the nonpigmented melanoma (two cases) and orange overlying the pigmented melanoma (two cases). Fluorescein angiography demonstrated that the lipofuscin pigment displayed fluorescein blockage in all four cases. Optical coherence tomography revealed serous retinal detachment in all four cases. Fundus autofluorescence imaging showed discrete, bright hyperautofluorescence of the orange pigment separated by hypoautofluorescent voids. The melanoma was isoautofluorescent. CONCLUSIONS: Intracellular lipofuscin overlying small choroidal melanomas shows discrete and bright hyperautofluorescence. The brightness correlates directly with the clinically visible orange pigment.

AB - PURPOSE: To describe the autofluorescence features of orange pigment (intracellular lipofuscin) overlying small presumed choroidal melanomas. METHODS: The diagnostic testing results (fluorescein angiography, optical coherence tomography, and fundus autofluorescence imaging) for two patients with pigmented choroidal melanoma and two patients with nonpigmented choroidal melanoma were reviewed. RESULTS: Clinically, the intracellular lipofuscin pigment appeared brown overlying the nonpigmented melanoma (two cases) and orange overlying the pigmented melanoma (two cases). Fluorescein angiography demonstrated that the lipofuscin pigment displayed fluorescein blockage in all four cases. Optical coherence tomography revealed serous retinal detachment in all four cases. Fundus autofluorescence imaging showed discrete, bright hyperautofluorescence of the orange pigment separated by hypoautofluorescent voids. The melanoma was isoautofluorescent. CONCLUSIONS: Intracellular lipofuscin overlying small choroidal melanomas shows discrete and bright hyperautofluorescence. The brightness correlates directly with the clinically visible orange pigment.

KW - Autofluorescence

KW - Choroidal melanoma

KW - Eye tumor

KW - Lipofuscin

KW - Nonpigmented

KW - Orange pigment

KW - Pigmented

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Autofluorescence of orange pigment overlying small choroidal melanoma

Abstract

Keywords

ASJC Scopus subject areas

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