Autofluorescence of orange pigment overlying small choroidal melanoma

Carol L. Shields, Carlos Bianciotto, Cesare Pirondini, Miguel A. Materin, Sarah A. Harmon, Jerry A. Shields

Research output: Contribution to journalArticlepeer-review


PURPOSE: To describe the autofluorescence features of orange pigment (intracellular lipofuscin) overlying small presumed choroidal melanomas. METHODS: The diagnostic testing results (fluorescein angiography, optical coherence tomography, and fundus autofluorescence imaging) for two patients with pigmented choroidal melanoma and two patients with nonpigmented choroidal melanoma were reviewed. RESULTS: Clinically, the intracellular lipofuscin pigment appeared brown overlying the nonpigmented melanoma (two cases) and orange overlying the pigmented melanoma (two cases). Fluorescein angiography demonstrated that the lipofuscin pigment displayed fluorescein blockage in all four cases. Optical coherence tomography revealed serous retinal detachment in all four cases. Fundus autofluorescence imaging showed discrete, bright hyperautofluorescence of the orange pigment separated by hypoautofluorescent voids. The melanoma was isoautofluorescent. CONCLUSIONS: Intracellular lipofuscin overlying small choroidal melanomas shows discrete and bright hyperautofluorescence. The brightness correlates directly with the clinically visible orange pigment.

Original languageEnglish
Pages (from-to)1107-1111
Number of pages5
Issue number8
Publication statusPublished - Oct 2007


  • Autofluorescence
  • Choroidal melanoma
  • Eye tumor
  • Lipofuscin
  • Nonpigmented
  • Orange pigment
  • Pigmented

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems


Dive into the research topics of 'Autofluorescence of orange pigment overlying small choroidal melanoma'. Together they form a unique fingerprint.

Cite this