TY - JOUR
T1 - Atrial fibrillation and microRNAs
AU - Santulli, Gaetano
AU - Iaccarino, Guido
AU - De Luca, Nicola
AU - Trimarco, Bruno
AU - Condorelli, Gianluigi
PY - 2014
Y1 - 2014
N2 - Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia. This report represents a systematic and updated appraisal of the main studies that established a mechanistic association between specific microRNAs and AF, focusing both on the regulation of electrical and structural remodeling of cardiac tissue.
AB - Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia. This report represents a systematic and updated appraisal of the main studies that established a mechanistic association between specific microRNAs and AF, focusing both on the regulation of electrical and structural remodeling of cardiac tissue.
KW - Apoptosis
KW - Atrial fibrillation
KW - Electrical remodeling
KW - Electrophysiology
KW - Fibrosis
KW - MicroRNA (miRNA)
KW - Structural remodeling
UR - http://www.scopus.com/inward/record.url?scp=84893489424&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893489424&partnerID=8YFLogxK
U2 - 10.3389/fphys.2014.00015
DO - 10.3389/fphys.2014.00015
M3 - Article
AN - SCOPUS:84893489424
SN - 1664-042X
VL - 5 JAN
JO - Frontiers in Physiology
JF - Frontiers in Physiology
M1 - 00015
ER -