At least three human homeoboxes on chromosome 12 belong to the same transcription unit

Antonio Simeone; Maria Pannese; Dario Acampora; Maurizio D'esposito; Edoardo Boncinelli

doi:10.1093/nar/16.12.5379

At least three human homeoboxes on chromosome 12 belong to the same transcription unit

Antonio Simeone, Maria Pannese, Dario Acampora, Maurizio D'esposito, Edoardo Boncinelli

Research output: Contribution to journal › Article › peer-review

Abstract

Mammalian homeoboxes show a clustered chromosomal organization. In the mouse, at least seven homeoboxes on chromosome 6 and at least six on chromosome 11 identify the murine Hox-1 and Hox-2 loci, respectively. A number of homeoboxes on chromosome 7 define the human HOX-1 locus and homeoboxes on chromosome 17 define the human HOX-2 locus. We studied the genomic organization of three homeobox sequences of the HOX-3 locus on chromosome 12 and analyzed transcripts from this region. Structural characterization and sequencing of several cDNA clones reveal that the three homeobox sequences present in this chromosomal region identify a single transcription unit. Primary transcripts are alternatively processed to give mature messengers with a common 5′ noncoding exon encoding different proteins containing one of the three homeodomains.

Original language	English
Pages (from-to)	5379-5390
Number of pages	12
Journal	Nucleic Acids Research
Volume	16
Issue number	12
DOIs	https://doi.org/10.1093/nar/16.12.5379
Publication status	Published - Jun 24 1988

ASJC Scopus subject areas

Statistics, Probability and Uncertainty
Applied Mathematics
Health, Toxicology and Mutagenesis
Toxicology
Genetics(clinical)
Genetics

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abstract = "Mammalian homeoboxes show a clustered chromosomal organization. In the mouse, at least seven homeoboxes on chromosome 6 and at least six on chromosome 11 identify the murine Hox-1 and Hox-2 loci, respectively. A number of homeoboxes on chromosome 7 define the human HOX-1 locus and homeoboxes on chromosome 17 define the human HOX-2 locus. We studied the genomic organization of three homeobox sequences of the HOX-3 locus on chromosome 12 and analyzed transcripts from this region. Structural characterization and sequencing of several cDNA clones reveal that the three homeobox sequences present in this chromosomal region identify a single transcription unit. Primary transcripts are alternatively processed to give mature messengers with a common 5′ noncoding exon encoding different proteins containing one of the three homeodomains.",

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AU - Simeone, Antonio

AU - Pannese, Maria

AU - Acampora, Dario

AU - D'esposito, Maurizio

AU - Boncinelli, Edoardo

PY - 1988/6/24

Y1 - 1988/6/24

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AB - Mammalian homeoboxes show a clustered chromosomal organization. In the mouse, at least seven homeoboxes on chromosome 6 and at least six on chromosome 11 identify the murine Hox-1 and Hox-2 loci, respectively. A number of homeoboxes on chromosome 7 define the human HOX-1 locus and homeoboxes on chromosome 17 define the human HOX-2 locus. We studied the genomic organization of three homeobox sequences of the HOX-3 locus on chromosome 12 and analyzed transcripts from this region. Structural characterization and sequencing of several cDNA clones reveal that the three homeobox sequences present in this chromosomal region identify a single transcription unit. Primary transcripts are alternatively processed to give mature messengers with a common 5′ noncoding exon encoding different proteins containing one of the three homeodomains.

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At least three human homeoboxes on chromosome 12 belong to the same transcription unit

Abstract

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