TY - JOUR
T1 - Association of the mitochondrial DNA haplogroup J with longevity is population specific
AU - Dato, Serena
AU - Passarino, Giuseppe
AU - Rose, Giuseppina
AU - Altomare, Katia
AU - Bellizzi, Dina
AU - Mari, Vincenzo
AU - Feraco, Emidio
AU - Franceschi, Claudio
AU - De Benedictis, Giovanna
PY - 2004/12
Y1 - 2004/12
N2 - Evidences are accumulating on the effects of the variability of mitochondrial DNA (mtDNA) on many complex traits. In particular, mtDNA haplogroup J has been reported to increase the individual chance to attain longevity in northern Italians, Northern Irish and Finns. However, since the genetic contribution to longevity may be population specific, we wanted to verify if haplogroup J does affect longevity also in a southern European population having a different genetic and environmental history. We analysed a population sample (883 subjects, 371 males and 521 females; age range 18-108 years) from southern Italy for the presence of haplogroup J. No frequency increase of this mtDNA haplogroup was found in the older cohorts, suggesting that, in this population, haplogroup J does not play a significant role in longevity. This finding shows that, as for other genetic factors, the association of mtDNA inherited variability with longevity is population specific.
AB - Evidences are accumulating on the effects of the variability of mitochondrial DNA (mtDNA) on many complex traits. In particular, mtDNA haplogroup J has been reported to increase the individual chance to attain longevity in northern Italians, Northern Irish and Finns. However, since the genetic contribution to longevity may be population specific, we wanted to verify if haplogroup J does affect longevity also in a southern European population having a different genetic and environmental history. We analysed a population sample (883 subjects, 371 males and 521 females; age range 18-108 years) from southern Italy for the presence of haplogroup J. No frequency increase of this mtDNA haplogroup was found in the older cohorts, suggesting that, in this population, haplogroup J does not play a significant role in longevity. This finding shows that, as for other genetic factors, the association of mtDNA inherited variability with longevity is population specific.
KW - Aging
KW - Genetic variability
KW - Longevity
KW - mtDNA
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U2 - 10.1038/sj.ejhg.5201278
DO - 10.1038/sj.ejhg.5201278
M3 - Article
C2 - 15470367
AN - SCOPUS:10044270764
SN - 1018-4813
VL - 12
SP - 1080
EP - 1082
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
IS - 12
ER -