TY - JOUR
T1 - Association of the CBLB gene with multiple sclerosis
T2 - New evidence from a replication study in an Italian population
AU - Corrado, Lucia
AU - Bergamaschi, Laura
AU - Barizzone, Nadia
AU - Fasano, Maria Edvige
AU - Guerini, Franca R.
AU - Salvetti, Marco
AU - Galimberti, Daniela
AU - Benedetti, Maria Donata
AU - Leone, Maurizio
AU - D'Alfonso, Sandra
PY - 2011/3
Y1 - 2011/3
N2 - Background: The T allele of rs9657904 within the CBLB gene was recently found to be significantly associated with multiple sclerosis (MS) in a genome-wide association study in Sardinia. Objective: To replicate this association in an independent population with a different genetic background. Methods: The rs9657904 variant was typed in a sample of 1435 cases and 1466 controls from the Italian mainland. Results: It was found that in this sample also, the common allele T of rs9657904 is significantly positively associated (one-tailed p = 7.35×10-5) and with a comparable effect size with MS (OR=1.31, 95% CI 1.14 to 1.52). Conclusion: These data provide further evidence of the association of MS disease with variation within CBLB.
AB - Background: The T allele of rs9657904 within the CBLB gene was recently found to be significantly associated with multiple sclerosis (MS) in a genome-wide association study in Sardinia. Objective: To replicate this association in an independent population with a different genetic background. Methods: The rs9657904 variant was typed in a sample of 1435 cases and 1466 controls from the Italian mainland. Results: It was found that in this sample also, the common allele T of rs9657904 is significantly positively associated (one-tailed p = 7.35×10-5) and with a comparable effect size with MS (OR=1.31, 95% CI 1.14 to 1.52). Conclusion: These data provide further evidence of the association of MS disease with variation within CBLB.
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U2 - 10.1136/jmg.2010.081380
DO - 10.1136/jmg.2010.081380
M3 - Article
C2 - 21037273
AN - SCOPUS:79951796542
SN - 0022-2593
VL - 48
SP - 210
EP - 211
JO - Journal of Medical Genetics
JF - Journal of Medical Genetics
IS - 3
ER -