TY - JOUR
T1 - Association between serum uric acid, hypertension, vascular stiffness and subclinical atherosclerosis
T2 - Data from the Brisighella Heart Study
AU - Cicero, Arrigo F G
AU - Salvi, Paolo
AU - D'Addato, Sergio
AU - Rosticci, Martina
AU - Borghi, Claudio
PY - 2014/1
Y1 - 2014/1
N2 - OBJECTIVE: Serum uric acid (SUA) levels correlate with many recognized cardiovascular risk factors, including age, male sex, hypertension, diabetes mellitus, hypertriglyceridemia, obesity, and insulin resistance. The aim of our study was to verify in a large well characterized population sample the relationship between SUA values, hypertension, arterial stiffness and subclinical atherosclerosis. METHODS: For this study, we selected 248 men and 371 women adult patients enrolled in the last Brisighella Heart Study population survey for which a full set of data were available and not consuming antihypertensive, antidiabetic, lipid-lowering and uric acid-lowering drugs. SUA and other available variables were related to blood pressure level, carotid-femoral pulse wave velocity (cfPWV) and carotid intima-media thickness (cIMT). RESULTS: Hypertension prevalence was strongly related to SUA quartiles: we found significant differences between the 2nd (23.0%) and the 3rd quartiles (36.4%; P vs. 2nd
AB - OBJECTIVE: Serum uric acid (SUA) levels correlate with many recognized cardiovascular risk factors, including age, male sex, hypertension, diabetes mellitus, hypertriglyceridemia, obesity, and insulin resistance. The aim of our study was to verify in a large well characterized population sample the relationship between SUA values, hypertension, arterial stiffness and subclinical atherosclerosis. METHODS: For this study, we selected 248 men and 371 women adult patients enrolled in the last Brisighella Heart Study population survey for which a full set of data were available and not consuming antihypertensive, antidiabetic, lipid-lowering and uric acid-lowering drugs. SUA and other available variables were related to blood pressure level, carotid-femoral pulse wave velocity (cfPWV) and carotid intima-media thickness (cIMT). RESULTS: Hypertension prevalence was strongly related to SUA quartiles: we found significant differences between the 2nd (23.0%) and the 3rd quartiles (36.4%; P vs. 2nd
KW - Hypertension
KW - Intima-media thickness
KW - Pulse wave velocity
KW - Serum uric acid
UR - http://www.scopus.com/inward/record.url?scp=84891559949&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891559949&partnerID=8YFLogxK
U2 - 10.1097/HJH.0b013e328365b916
DO - 10.1097/HJH.0b013e328365b916
M3 - Article
C2 - 24309486
AN - SCOPUS:84891559949
SN - 0263-6352
VL - 32
SP - 57
EP - 64
JO - Journal of Hypertension
JF - Journal of Hypertension
IS - 1
ER -