Association between ramucirumab-related hypertension and response to treatment in patients with metastatic gastric cancer

Giandomenico Roviello, Silvia Paola Corona, Andrea Giovanni Multari, Giovanni Paganini, Giorgio Chiriacò, Raffaele Conca, Roberto Petrioli, Daniele Generali, Pietro Rosellini, Michele Aieta

Research output: Contribution to journalArticlepeer-review


Purpose. Hypertension (HTN) is frequently associated with the use of angiogenesis inhibitors targeting the vascular endothelial growth factor pathway, such as ramucirumab. The aim of this study was to retrospectively evaluate if occurrence of HTN is correlated with response to second line treatment with ramucirumab+paclitaxel for metastatic gastric cancer. Methods. Treatment consisted of ramucirumab 8 mg/kg intravenously (iv) on days 1 and 15, plus paclitaxel 80 mg/m2 iv on days 1, 8, and 15 of a 28-day cycle. Patients received study treatment until disease progression, unacceptable toxicity, or withdrawal of consent. Results. Thirty-four patients were retrospectively evaluated. Among these, 6 (17.6%) developed grade 3 ramucirumab-induced HTN. These patients had a better outcome than those with lesser grades events, with a progression-free survival (PFS) of 7.8 months (95% CI 4.4-not reached) versus 4.2 months (95% CI 3.1-5.2) (p=0.001). overall survival (OS) was 11.9 months (95% CI 9.3-not reached) in the grade 3 HTN group, versus 7.2 months (95% CI 5.9-10.1). Conclusions. Despite the small number of patients and the retrospective nature of the data, our analysis showed that occurrence of ramucirumab-related HTN, in particular G3 HTN, predicts response to treatment with ramucirumab+paclitaxel in patients with metastatic gastric cancer.

Original languageEnglish
Pages (from-to)22332-22339
Number of pages8
Issue number32
Publication statusPublished - Apr 27 2018


  • Gastric cancer
  • Hypertension
  • Ramucirumab

ASJC Scopus subject areas

  • Oncology


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