Association between plasma omentin-1 levels in type 2 diabetic patients and peripheral artery disease

Federico Biscetti; Elisabetta Nardella; Nicola Bonadia; Flavia Angelini; Dario Pitocco; Angelo Santoliquido; Marco Filipponi; Raffaele Landolfi; Andrea Flex

doi:10.1186/s12933-019-0880-7

Association between plasma omentin-1 levels in type 2 diabetic patients and peripheral artery disease

Federico Biscetti, Elisabetta Nardella, Nicola Bonadia, Flavia Angelini, Dario Pitocco, Angelo Santoliquido, Marco Filipponi, Raffaele Landolfi, Andrea Flex

IRCCS Fondazione Policlinico Universitario A. Gemelli

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Type-2 diabetes mellitus is one of the major risk factors of atherosclerosis, particularly in peripheral artery disease (PAD). Several studies have documented a correlation between omentin-1 serum levels, atherosclerosis, and cardiovascular diseases. However, a clear link between circulating omentin-1 and PAD in diabetic patients has yet to be established. The aim of this study was to investigate the potential role of omentin-1 in PAD in type-2 diabetic patients.

METHODS: In this cross-sectional study, we analyzed omentin-1 serum levels by ELISA in 600 type-2 diabetic patients with (n = 300) and without (n = 300) PAD at Fontaine's stage II, III, or IV.

RESULTS: We found that omentin-1 serum levels were significantly lower in diabetic patients with PAD than in diabetic controls (29.46 vs 49.24 ng/mL, P < 0.001) and that the levels gradually decreased in proportion to disease severity (P < 0.05). The association between omentin-1 levels and PAD remained significant after adjusting for major risk factors in a multivariate analysis.

CONCLUSIONS: Our results suggest that omentin-1 is reduced in type 2 diabetic patients with PAD and that omentin-1 levels are related to disease severity.

Original language	English
Pages (from-to)	74
Journal	Cardiovascular Diabetology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s12933-019-0880-7
Publication status	Published - Jun 5 2019

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title = "Association between plasma omentin-1 levels in type 2 diabetic patients and peripheral artery disease",

abstract = "BACKGROUND: Type-2 diabetes mellitus is one of the major risk factors of atherosclerosis, particularly in peripheral artery disease (PAD). Several studies have documented a correlation between omentin-1 serum levels, atherosclerosis, and cardiovascular diseases. However, a clear link between circulating omentin-1 and PAD in diabetic patients has yet to be established. The aim of this study was to investigate the potential role of omentin-1 in PAD in type-2 diabetic patients.METHODS: In this cross-sectional study, we analyzed omentin-1 serum levels by ELISA in 600 type-2 diabetic patients with (n = 300) and without (n = 300) PAD at Fontaine's stage II, III, or IV.RESULTS: We found that omentin-1 serum levels were significantly lower in diabetic patients with PAD than in diabetic controls (29.46 vs 49.24 ng/mL, P < 0.001) and that the levels gradually decreased in proportion to disease severity (P < 0.05). The association between omentin-1 levels and PAD remained significant after adjusting for major risk factors in a multivariate analysis.CONCLUSIONS: Our results suggest that omentin-1 is reduced in type 2 diabetic patients with PAD and that omentin-1 levels are related to disease severity.",

author = "Federico Biscetti and Elisabetta Nardella and Nicola Bonadia and Flavia Angelini and Dario Pitocco and Angelo Santoliquido and Marco Filipponi and Raffaele Landolfi and Andrea Flex",

year = "2019",

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doi = "10.1186/s12933-019-0880-7",

language = "English",

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journal = "Cardiovascular Diabetology",

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number = "1",

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TY - JOUR

T1 - Association between plasma omentin-1 levels in type 2 diabetic patients and peripheral artery disease

AU - Biscetti, Federico

AU - Nardella, Elisabetta

AU - Bonadia, Nicola

AU - Angelini, Flavia

AU - Pitocco, Dario

AU - Santoliquido, Angelo

AU - Filipponi, Marco

AU - Landolfi, Raffaele

AU - Flex, Andrea

PY - 2019/6/5

Y1 - 2019/6/5

N2 - BACKGROUND: Type-2 diabetes mellitus is one of the major risk factors of atherosclerosis, particularly in peripheral artery disease (PAD). Several studies have documented a correlation between omentin-1 serum levels, atherosclerosis, and cardiovascular diseases. However, a clear link between circulating omentin-1 and PAD in diabetic patients has yet to be established. The aim of this study was to investigate the potential role of omentin-1 in PAD in type-2 diabetic patients.METHODS: In this cross-sectional study, we analyzed omentin-1 serum levels by ELISA in 600 type-2 diabetic patients with (n = 300) and without (n = 300) PAD at Fontaine's stage II, III, or IV.RESULTS: We found that omentin-1 serum levels were significantly lower in diabetic patients with PAD than in diabetic controls (29.46 vs 49.24 ng/mL, P < 0.001) and that the levels gradually decreased in proportion to disease severity (P < 0.05). The association between omentin-1 levels and PAD remained significant after adjusting for major risk factors in a multivariate analysis.CONCLUSIONS: Our results suggest that omentin-1 is reduced in type 2 diabetic patients with PAD and that omentin-1 levels are related to disease severity.

AB - BACKGROUND: Type-2 diabetes mellitus is one of the major risk factors of atherosclerosis, particularly in peripheral artery disease (PAD). Several studies have documented a correlation between omentin-1 serum levels, atherosclerosis, and cardiovascular diseases. However, a clear link between circulating omentin-1 and PAD in diabetic patients has yet to be established. The aim of this study was to investigate the potential role of omentin-1 in PAD in type-2 diabetic patients.METHODS: In this cross-sectional study, we analyzed omentin-1 serum levels by ELISA in 600 type-2 diabetic patients with (n = 300) and without (n = 300) PAD at Fontaine's stage II, III, or IV.RESULTS: We found that omentin-1 serum levels were significantly lower in diabetic patients with PAD than in diabetic controls (29.46 vs 49.24 ng/mL, P < 0.001) and that the levels gradually decreased in proportion to disease severity (P < 0.05). The association between omentin-1 levels and PAD remained significant after adjusting for major risk factors in a multivariate analysis.CONCLUSIONS: Our results suggest that omentin-1 is reduced in type 2 diabetic patients with PAD and that omentin-1 levels are related to disease severity.

U2 - 10.1186/s12933-019-0880-7

DO - 10.1186/s12933-019-0880-7

M3 - Article

C2 - 31167666

SN - 1475-2840

VL - 18

SP - 74

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

IS - 1

ER -

Association between plasma omentin-1 levels in type 2 diabetic patients and peripheral artery disease

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