TY - JOUR
T1 - Association between GSK-3β -50T/C polymorphism and personality and psychotic symptoms in mood disorders
AU - Serretti, Alessandro
AU - Benedetti, Francesco
AU - Mandelli, Laura
AU - Calati, Raffaella
AU - Caneva, Barbara
AU - Lorenzi, Cristina
AU - Fontana, Valentina
AU - Colombo, Cristina
AU - Smeraldi, Enrico
PY - 2008/3/15
Y1 - 2008/3/15
N2 - The exact role of the enzyme glycogen synthase kinase 3β (GSK-3β) in mood disorders is still unknown. GSK-3β has been mapped to chromosome 3q13.3, a potential susceptibility locus for bipolar disorder. The -50T/C polymorphism, falling within the promoter region of the gene coding for GSK-3β, was previously reported to be associated with age at onset, therapeutic response to lithium salts and total sleep deprivation in bipolar patients. In the present study we investigated the association between the -50T/C polymorphism and both symptomatic and personality features in mood disorders. The sample comprised 365 inpatients affected by major depressive disorder and bipolar disorder, genotyped for the GSK-3β-50 polymorphism and assessed with the Operational Criteria Checklist for Psychotic Illness (OPCRIT). Ninety-five subjects were also evaluated with the Temperament and Character Inventory (TCI). The GSK-3β-50 polymorphism showed a positive association with delusional symptomatology and with the personality features linked to Self-Transcendence. Finally, GSK-3β-50 and personality showed an interactive effect on delusional scores. In conclusion, our findings support the role of GSK-3β-50 in both normal and psychopathological aspects of human cognition and further suggest a possible interaction between genes and personality in the liability to psychotic disorders.
AB - The exact role of the enzyme glycogen synthase kinase 3β (GSK-3β) in mood disorders is still unknown. GSK-3β has been mapped to chromosome 3q13.3, a potential susceptibility locus for bipolar disorder. The -50T/C polymorphism, falling within the promoter region of the gene coding for GSK-3β, was previously reported to be associated with age at onset, therapeutic response to lithium salts and total sleep deprivation in bipolar patients. In the present study we investigated the association between the -50T/C polymorphism and both symptomatic and personality features in mood disorders. The sample comprised 365 inpatients affected by major depressive disorder and bipolar disorder, genotyped for the GSK-3β-50 polymorphism and assessed with the Operational Criteria Checklist for Psychotic Illness (OPCRIT). Ninety-five subjects were also evaluated with the Temperament and Character Inventory (TCI). The GSK-3β-50 polymorphism showed a positive association with delusional symptomatology and with the personality features linked to Self-Transcendence. Finally, GSK-3β-50 and personality showed an interactive effect on delusional scores. In conclusion, our findings support the role of GSK-3β-50 in both normal and psychopathological aspects of human cognition and further suggest a possible interaction between genes and personality in the liability to psychotic disorders.
KW - Bipolar disorder
KW - Delusion
KW - Genetics
KW - GSK-3β
KW - Major depressive disorder
KW - Personality
KW - Psychotic symptoms
UR - http://www.scopus.com/inward/record.url?scp=39749095969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39749095969&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2007.06.017
DO - 10.1016/j.psychres.2007.06.017
M3 - Article
C2 - 17976739
AN - SCOPUS:39749095969
SN - 0165-1781
VL - 158
SP - 132
EP - 140
JO - Psychiatry Research
JF - Psychiatry Research
IS - 2
ER -