Aspartame and the rat brain monoaminergic system

C. Perego; M. G. De Simoni; F. Fodritto; L. Raimondi; L. Diomede; M. Salmona; S. Algeri; S. Garattini

doi:10.1016/0378-4274(88)90172-5

Aspartame and the rat brain monoaminergic system

C. Perego, M. G. De Simoni, F. Fodritto, L. Raimondi, L. Diomede, M. Salmona, S. Algeri, S. Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

A high dose of aspartame (APM) was administered to rats to study possible effects on brain monoaminergic systems. APM and its metabolite phenylalanine (Phe) were given orally at doses of 1000 and 500 mg/kg, respectively. Significant increases were seen in brain Phe and tyrosine (Tyr) levels. Two different approaches were used to study monoaminergic systems: whole tissue measurements by HPLC-ED and in vivo voltammetry in freely moving rats. Dopamine, serotonin and their metabolites were taken as indexes of neuronal activity. In spite of the high dose used, no modification was found in monoamines or their metabolites in striatum, hippocampus and nucleus accumbens.

Original language	English
Pages (from-to)	331-339
Number of pages	9
Journal	Toxicology Letters
Volume	44
Issue number	3
DOIs	https://doi.org/10.1016/0378-4274(88)90172-5
Publication status	Published - 1988

Keywords

Aspartame
Dopaminergic system
Phenylalanine
Plasma and brain amino acids
Serotonergic system

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(88)90172-5

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abstract = "A high dose of aspartame (APM) was administered to rats to study possible effects on brain monoaminergic systems. APM and its metabolite phenylalanine (Phe) were given orally at doses of 1000 and 500 mg/kg, respectively. Significant increases were seen in brain Phe and tyrosine (Tyr) levels. Two different approaches were used to study monoaminergic systems: whole tissue measurements by HPLC-ED and in vivo voltammetry in freely moving rats. Dopamine, serotonin and their metabolites were taken as indexes of neuronal activity. In spite of the high dose used, no modification was found in monoamines or their metabolites in striatum, hippocampus and nucleus accumbens.",

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T1 - Aspartame and the rat brain monoaminergic system

AU - Perego, C.

AU - De Simoni, M. G.

AU - Fodritto, F.

AU - Raimondi, L.

AU - Diomede, L.

AU - Salmona, M.

AU - Algeri, S.

AU - Garattini, S.

PY - 1988

Y1 - 1988

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KW - Aspartame

KW - Dopaminergic system

KW - Phenylalanine

KW - Plasma and brain amino acids

KW - Serotonergic system

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Aspartame and the rat brain monoaminergic system

Abstract

Keywords

ASJC Scopus subject areas

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