Aspartame and the rat brain monoaminergic system

C. Perego, M. G. De Simoni, F. Fodritto, L. Raimondi, L. Diomede, M. Salmona, S. Algeri, S. Garattini

Research output: Contribution to journalArticlepeer-review


A high dose of aspartame (APM) was administered to rats to study possible effects on brain monoaminergic systems. APM and its metabolite phenylalanine (Phe) were given orally at doses of 1000 and 500 mg/kg, respectively. Significant increases were seen in brain Phe and tyrosine (Tyr) levels. Two different approaches were used to study monoaminergic systems: whole tissue measurements by HPLC-ED and in vivo voltammetry in freely moving rats. Dopamine, serotonin and their metabolites were taken as indexes of neuronal activity. In spite of the high dose used, no modification was found in monoamines or their metabolites in striatum, hippocampus and nucleus accumbens.

Original languageEnglish
Pages (from-to)331-339
Number of pages9
JournalToxicology Letters
Issue number3
Publication statusPublished - 1988


  • Aspartame
  • Dopaminergic system
  • Phenylalanine
  • Plasma and brain amino acids
  • Serotonergic system

ASJC Scopus subject areas

  • Toxicology


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