ART results with frozen oocytes: data from the Italian ART registry (2005–2013)

Paolo Emanuele P E Levi-Setti, Andrea Borini, Pasquale Patrizio, Simone Bolli, Vincenzo Vigiliano, Roberto De Luca, Giulia Scaravelli

Research output: Contribution to journalArticlepeer-review


Purpose: This study is a retrospective collection of aggregated data from all the Italian ART centers reporting to the Italian National Register from cycles started between January 2005 and December 2013. Methods: Data from both slow freezing (SF) and vitrification (V) were assessed for the period 2007–2013, while during the years 2005–2006 cryopreservation was exclusively performed by SF. Results: In the study period, a total of 2,526,024 oocytes were retrieved (from 378,543 retrievals), of which 1,346,061 (53.3 %) were inseminated in fresh cycles and 214,481 (8.5 %) were cryopreserved. Cryopreserved oocytes were used in 24,173 cycles yielding 19,453 transfer cycles (80.5 % of the thawing/warming cycles) and 3043 clinical pregnancies (15.6 % per transfer). A significant difference in implantation (8.7 vs 12.9 % OR 1.30 CI 1.20–1.40) and pregnancy rates per transfer (12.2 vs 14.9 % OR 1.34 CI 1.23–1.46) was found between SF and V. Complete outcome data was available for 2708 pregnancies (89.8 %), leading to 1882 deliveries and 2152 live births. Neonatal major congenital anomalies were 0.9 % (20/2152). Conclusions: A wide variation in pregnancy rates were found among different centers and lower rates were reported in donor cycles and in centers with more experience.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalJournal of Assisted Reproduction and Genetics
Issue number1
Publication statusPublished - Jan 1 2016


  • ART registry
  • Congenital anomalies
  • Cumulative ART pregnancy rate
  • Oocyte freezing
  • Safety in ART

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Developmental Biology
  • Genetics
  • Genetics(clinical)


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