TY - JOUR
T1 - Aptamer Functionalization of Nanosystems for Glioblastoma Targeting through the Blood-Brain Barrier
AU - Monaco, Ilaria
AU - Camorani, Simona
AU - Colecchia, David
AU - Locatelli, Erica
AU - Calandro, Pierpaolo
AU - Oudin, Anais
AU - Niclou, Simone P.
AU - Arra, Claudio
AU - Chiariello, Mario
AU - Cerchia, Laura
AU - Comes Franchini, Mauro
PY - 2017/5/25
Y1 - 2017/5/25
N2 - Polymeric nanoparticles (PNPs) may efficiently deliver in vivo therapeutics to tumors when conjugated to specific targeting agents. Gint4.T aptamer specifically recognizes platelet-derived growth factor receptor β and can cross the blood-brain barrier (BBB). We synthesized Gint4.T-conjugated PNPs able of high uptake into U87MG glioblastoma (GBM) cells and with astonishing EC50 value (38 pM) when loaded with a PI3K-mTOR inhibitor. We also demonstrated in vivo BBB passage and tumor accumulation in a GBM orthotopic model.
AB - Polymeric nanoparticles (PNPs) may efficiently deliver in vivo therapeutics to tumors when conjugated to specific targeting agents. Gint4.T aptamer specifically recognizes platelet-derived growth factor receptor β and can cross the blood-brain barrier (BBB). We synthesized Gint4.T-conjugated PNPs able of high uptake into U87MG glioblastoma (GBM) cells and with astonishing EC50 value (38 pM) when loaded with a PI3K-mTOR inhibitor. We also demonstrated in vivo BBB passage and tumor accumulation in a GBM orthotopic model.
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U2 - 10.1021/acs.jmedchem.7b00527
DO - 10.1021/acs.jmedchem.7b00527
M3 - Article
AN - SCOPUS:85019721372
SN - 0022-2623
VL - 60
SP - 4510
EP - 4516
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
IS - 10
ER -