Applications of extracorporeal photochemotherapy in 'non-oncological' diseases

R. Dall'Amico, F. Zulian, G. Montini, B. Andretta, L. Murer, F. Rossetti, U. Livi, G. Zacchello, F. Zacchello

Research output: Contribution to journalArticlepeer-review


Photopheresis (ECP) is a new therapy for oncological and autoimmune diseases consisting in the reinfusion of 3-9 x 109 leukocytes, taken from the patient by leukapheresis, and treated in an extracorporeal system with 8- methoxypsoralen and ultraviolet light A. Nine patients affected by T cell immunomediated diseases (2 scleroderma, 1 chronic GVHD, 1 polyarteritis, 1 rheumatoid arthritis and 4 heart transplant patients with numerous episodes of acute rejection) were treated with ECP. Photopheresis was performed on 2 consecutive days every 3-4 weeks. All patients affected by autoimmune diseases experienced an improvement during treatment with ECP. In 2 of the 4 patients with heart transplant, rejection was reversed by photopheresis. No major side effects were observed during the treatment. In conclusion ECP is a safe and well tolerated therapy. Although the number of patients is small ECP seems to be an effective modality in many diseases.

Original languageEnglish
Pages (from-to)168-172
Number of pages5
JournalInternational Journal of Artificial Organs
Issue numberSUPPL. 5
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Biophysics


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