Apoptosis, vascularity, and proliferation in primary central nervous system lymphomas (PCNSL): A histopathological study

Florian Roser, Marco Saini, Rainer Meliss, Helmut Ostertag, Madjid Samii, Mattia Bellinzona

Research output: Contribution to journalArticlepeer-review


Background In the present study apoptosis, vascularity, and proliferation were quantitatively analyzed with immunohistopathological techniques in primary central nervous system lymphomas (PCNSL). Statistical analysis of these parameters was performed to evaluate their possible relationship with the unfavorable outcome of this tumor. Methods A series of 32 PCNSL patients for a total of 33 tumors treated from 1984 to 2000 in the Neurosurgical Department were reviewed, and their histologic specimens examined for apoptosis, vascularity, and proliferation. Results Patients were treated with either gross total/subtotal tumor removal or stereotactic biopsy. Vascularity was studied by means of FVIII staining, proliferative index with Ki-67 staining, and apoptosis with the TUNEL technique. Most tumors could be classified as immunoblastic or centroblastic B-Cell NHL. Mean Mib-1 Labeling Index was 35.34% (5-80), blood vessel density of 40.8 per 10 high power fields. Apoptotic cells were zero or less than 8 cells per 10 high power fields. Conclusion No statistically significant correlation between survival and histopathological parameters could be shown. However, the apoptosis index was found to be negatively correlated with proliferative index and may account for a more aggressive clinical course of PCNSL.

Original languageEnglish
Pages (from-to)393-399
Number of pages7
JournalSurgical Neurology
Issue number5
Publication statusPublished - Nov 2004


  • apoptosis
  • brain
  • Ki-67
  • Lymphoma
  • vascularity

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery


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