Apolipoprotein E: Impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease

R. W. Mahley; B. P. Nathan; S. Bellosta; R. E. Pitas

Apolipoprotein E: Impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease

R. W. Mahley, B. P. Nathan, S. Bellosta, R. E. Pitas

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

Apolipoproteins E3 and E4 exert differential effects on neuronal growth in vitro. Apolipoprotein E3 supports neurite extension, whereas apolipoprotein E4 does not. These isoform-specific effects may influence the stability of the cytoskeleton and may account for the association of the apolipoprotein E4 isoform with the pathogenesis of Alzheimer's disease.

Original language	English
Pages (from-to)	86-91
Number of pages	6
Journal	Current Opinion in Lipidology
Volume	6
Issue number	2
Publication status	Published - 1995

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Apolipoprotein E: Impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease",

abstract = "Apolipoproteins E3 and E4 exert differential effects on neuronal growth in vitro. Apolipoprotein E3 supports neurite extension, whereas apolipoprotein E4 does not. These isoform-specific effects may influence the stability of the cytoskeleton and may account for the association of the apolipoprotein E4 isoform with the pathogenesis of Alzheimer's disease.",

author = "Mahley, {R. W.} and Nathan, {B. P.} and S. Bellosta and Pitas, {R. E.}",

year = "1995",

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AU - Pitas, R. E.

PY - 1995

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AB - Apolipoproteins E3 and E4 exert differential effects on neuronal growth in vitro. Apolipoprotein E3 supports neurite extension, whereas apolipoprotein E4 does not. These isoform-specific effects may influence the stability of the cytoskeleton and may account for the association of the apolipoprotein E4 isoform with the pathogenesis of Alzheimer's disease.

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Apolipoprotein E: Impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease

Abstract

ASJC Scopus subject areas

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