Apolipoprotein B gene polimorphism and plasma lipid levels in phenylketonuric children

Elvira Verduci; Carlo Agostoni; Maria Luisa Biondi; Giovanni Radaelli; Marcello Giovannini; Enrica Riva

doi:10.1016/j.plefa.2003.12.022

Apolipoprotein B gene polimorphism and plasma lipid levels in phenylketonuric children

Elvira Verduci, Carlo Agostoni, Maria Luisa Biondi, Giovanni Radaelli, Marcello Giovannini, Enrica Riva

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

The associations of apolipoprotein B (apoB) gene polymorphisms with blood lipid levels, also accounting for apo E polymorphisms, were assessed in 82 phenylketonuric (PKU) children on diet (34 girls, 48 boys, age 4-12 years, median 8 years). Dietary and plasma biochemical assessments were performed at six-month intervals from the age of 24 months onwards. Apo B (XbaI, MspI, EcoRI restricton sites) and apo E (E₂, E₃, E₄) gene polymorphisms were determined by restriction-enzyme analysis after DNA extraction from blood. Subgroups of apoB polymorphisms were similar for energy intake, dietary lipids and distribution of apo E polymorphisms. Children carrying XbaI X⁺/X⁺ showed higher plasma levels of LDL cholesterol than children carrying X^-/X^-/+. This gene-related response to dietary habits might play a role also in non-PKU individuals fed low-fat, low-cholesterol diets.

Original language	English
Pages (from-to)	117-120
Number of pages	4
Journal	Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume	71
Issue number	2
DOIs	https://doi.org/10.1016/j.plefa.2003.12.022
Publication status	Published - Aug 2004

ASJC Scopus subject areas

Clinical Biochemistry
Endocrinology, Diabetes and Metabolism

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title = "Apolipoprotein B gene polimorphism and plasma lipid levels in phenylketonuric children",

abstract = "The associations of apolipoprotein B (apoB) gene polymorphisms with blood lipid levels, also accounting for apo E polymorphisms, were assessed in 82 phenylketonuric (PKU) children on diet (34 girls, 48 boys, age 4-12 years, median 8 years). Dietary and plasma biochemical assessments were performed at six-month intervals from the age of 24 months onwards. Apo B (XbaI, MspI, EcoRI restricton sites) and apo E (E2, E3, E4) gene polymorphisms were determined by restriction-enzyme analysis after DNA extraction from blood. Subgroups of apoB polymorphisms were similar for energy intake, dietary lipids and distribution of apo E polymorphisms. Children carrying XbaI X+/X+ showed higher plasma levels of LDL cholesterol than children carrying X-/X-/+. This gene-related response to dietary habits might play a role also in non-PKU individuals fed low-fat, low-cholesterol diets.",

author = "Elvira Verduci and Carlo Agostoni and Biondi, {Maria Luisa} and Giovanni Radaelli and Marcello Giovannini and Enrica Riva",

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T1 - Apolipoprotein B gene polimorphism and plasma lipid levels in phenylketonuric children

AU - Verduci, Elvira

AU - Agostoni, Carlo

AU - Biondi, Maria Luisa

AU - Radaelli, Giovanni

AU - Giovannini, Marcello

AU - Riva, Enrica

PY - 2004/8

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N2 - The associations of apolipoprotein B (apoB) gene polymorphisms with blood lipid levels, also accounting for apo E polymorphisms, were assessed in 82 phenylketonuric (PKU) children on diet (34 girls, 48 boys, age 4-12 years, median 8 years). Dietary and plasma biochemical assessments were performed at six-month intervals from the age of 24 months onwards. Apo B (XbaI, MspI, EcoRI restricton sites) and apo E (E2, E3, E4) gene polymorphisms were determined by restriction-enzyme analysis after DNA extraction from blood. Subgroups of apoB polymorphisms were similar for energy intake, dietary lipids and distribution of apo E polymorphisms. Children carrying XbaI X+/X+ showed higher plasma levels of LDL cholesterol than children carrying X-/X-/+. This gene-related response to dietary habits might play a role also in non-PKU individuals fed low-fat, low-cholesterol diets.

AB - The associations of apolipoprotein B (apoB) gene polymorphisms with blood lipid levels, also accounting for apo E polymorphisms, were assessed in 82 phenylketonuric (PKU) children on diet (34 girls, 48 boys, age 4-12 years, median 8 years). Dietary and plasma biochemical assessments were performed at six-month intervals from the age of 24 months onwards. Apo B (XbaI, MspI, EcoRI restricton sites) and apo E (E2, E3, E4) gene polymorphisms were determined by restriction-enzyme analysis after DNA extraction from blood. Subgroups of apoB polymorphisms were similar for energy intake, dietary lipids and distribution of apo E polymorphisms. Children carrying XbaI X+/X+ showed higher plasma levels of LDL cholesterol than children carrying X-/X-/+. This gene-related response to dietary habits might play a role also in non-PKU individuals fed low-fat, low-cholesterol diets.

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ER -

Apolipoprotein B gene polimorphism and plasma lipid levels in phenylketonuric children

Abstract

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