Anxiety disorders in acute central nervous system infections

Elena Bozzola, Giulia Spina, Paola Bergonzini, Mauro Bozzola, Massimiliano Raponi, Alberto Villani

Research output: Contribution to journalArticlepeer-review


Background: Patients affected by acute central nervous system (ACNS) infectionsmay present different complications, including neuropsychological disorders. Nevertheless, psychopathological impairment has been rarely measured by appropriate and validated tests. Material and methods: Survivors of childhood ACNS infections admitted to the Bambino Gesù Children's Hospital, Rome, Italy, from June 2013 to June 2015 were re-evaluated at follow-up from June 2016 to June 2017. Both patients and their parents underwent a psychological interview and neuropsychological tests (the Leiter International Performance Scale - revised (Leiter-R), the Child Behaviour Checklist (CBCL), the K-SADS-PL test). Results: Thirty children were included in the study. The mean score of IQ and fluid reasoning was within the normal range. A percentage of 20% of the children enrolled showed criteria for generalized anxiety disorder. Conclusion: Our study revealed the importance of follow-up evaluations after ACNS infections, in order to prevent mayor psychological sequelae and to perform treatment or rehabilitation.

Original languageEnglish
Article number23
JournalItalian Journal of Pediatrics
Issue number1
Publication statusPublished - Feb 17 2020


  • Acute central nervous system infections
  • Children
  • Neuropsychological disorders

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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