Antitumor activity of the novel nitrosourea S10036 in rodent tumors

S. Filippeschi; T. Colombo; D. Bassani; L. De Francesco; P. Arioli; M. D'Incalci; I. Bartosek; A. Guaitani

Antitumor activity of the novel nitrosourea S10036 in rodent tumors

S. Filippeschi, T. Colombo, D. Bassani, L. De Francesco, P. Arioli, M. D'Incalci, I. Bartosek, A. Guaitani

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The activity of the novel anticancer agent diethyl 1-3-(chloroethyl)-3-nitrosoureido ethyl phosphonate (S10036) was investigated on several rodent tumors. S10036 showed a good efficacy, comparable to that of the anticancer agent BCNU, against i.p. transplanted P388 and L1210 leukemias. S10036 was very effective against the primary tumor and metastases of i.m. transplanted M5076 reticular cell sarcoma of the mouse and against subline A of the Walker carcinoma of the rat. It was inactive against rodent tumors resistant to BCNU such as L1210/BCNU, ICIG-Ci4 murine fibrosarcoma and the Walker carcinoma subline B in the rat.

Original language	English
Pages (from-to)	1351-1354
Number of pages	4
Journal	Anticancer Research
Volume	8
Issue number	6
Publication status	Published - 1988

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

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title = "Antitumor activity of the novel nitrosourea S10036 in rodent tumors",

abstract = "The activity of the novel anticancer agent diethyl 1-3-(chloroethyl)-3-nitrosoureido ethyl phosphonate (S10036) was investigated on several rodent tumors. S10036 showed a good efficacy, comparable to that of the anticancer agent BCNU, against i.p. transplanted P388 and L1210 leukemias. S10036 was very effective against the primary tumor and metastases of i.m. transplanted M5076 reticular cell sarcoma of the mouse and against subline A of the Walker carcinoma of the rat. It was inactive against rodent tumors resistant to BCNU such as L1210/BCNU, ICIG-Ci4 murine fibrosarcoma and the Walker carcinoma subline B in the rat.",

author = "S. Filippeschi and T. Colombo and D. Bassani and {De Francesco}, L. and P. Arioli and M. D'Incalci and I. Bartosek and A. Guaitani",

year = "1988",

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T1 - Antitumor activity of the novel nitrosourea S10036 in rodent tumors

AU - Filippeschi, S.

AU - Colombo, T.

AU - Bassani, D.

AU - De Francesco, L.

AU - Arioli, P.

AU - D'Incalci, M.

AU - Bartosek, I.

AU - Guaitani, A.

PY - 1988

Y1 - 1988

N2 - The activity of the novel anticancer agent diethyl 1-3-(chloroethyl)-3-nitrosoureido ethyl phosphonate (S10036) was investigated on several rodent tumors. S10036 showed a good efficacy, comparable to that of the anticancer agent BCNU, against i.p. transplanted P388 and L1210 leukemias. S10036 was very effective against the primary tumor and metastases of i.m. transplanted M5076 reticular cell sarcoma of the mouse and against subline A of the Walker carcinoma of the rat. It was inactive against rodent tumors resistant to BCNU such as L1210/BCNU, ICIG-Ci4 murine fibrosarcoma and the Walker carcinoma subline B in the rat.

AB - The activity of the novel anticancer agent diethyl 1-3-(chloroethyl)-3-nitrosoureido ethyl phosphonate (S10036) was investigated on several rodent tumors. S10036 showed a good efficacy, comparable to that of the anticancer agent BCNU, against i.p. transplanted P388 and L1210 leukemias. S10036 was very effective against the primary tumor and metastases of i.m. transplanted M5076 reticular cell sarcoma of the mouse and against subline A of the Walker carcinoma of the rat. It was inactive against rodent tumors resistant to BCNU such as L1210/BCNU, ICIG-Ci4 murine fibrosarcoma and the Walker carcinoma subline B in the rat.

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Antitumor activity of the novel nitrosourea S10036 in rodent tumors

Abstract

ASJC Scopus subject areas

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