Antithyroid drugs in Graves’ hyperthyroidism: differences between “block and replace” and “titration” regimes in frequency of euthyroidism and Graves’ orbitopathy during treatment

EUGOGO (European Group on Graves’ Orbitopathy), M. Žarković, W. Wiersinga, P. Perros, L. Bartalena, S. Donati, O. Okosieme, D. Morris, N. Fichter, J. Lareida, C. Daumerie, M. C. Burlacu, G. J. Kahaly, S. Pitz, B. Beleslin, J. Ćirić, G. Ayvaz, O. Konuk, F. B. Törüner, M. SalviD. Covelli, N. Curro, L. Hegedüs, T. Brix

Research output: Contribution to journalArticlepeer-review


Purpose: Whereas antithyroid drugs (ATD) are the preferred treatment modality for Graves’ hyperthyroidism (GH), there is still controversy about the optimal regimen for delivering ATD. To evaluate whether ‘Block and Replace’ (B + R) and ‘Titration’ (T) regimes are equivalent in terms of frequency of euthyroidism and Graves’ Orbitopathy (GO) during ATD therapy. Methods: A prospective multicentre observational cohort study of 344 patients with GH but no GO at baseline. Patients were treated with ATD for 18 months according to B + R or T regimen in line with their institution’s policy. Results: Baseline characteristics were similar in both groups. In the treatment period between 6 and 18 months thyrotropin (TSH) slightly increased in both groups, but TSH was on average 0.59 mU/L (95% CI 0.27–0.85) lower in the B + R group at all time points (p = 0.026). Serum free thyroxine (FT4) remained stable during the same interval, with a tendency to higher values in the B + R group. The point-prevalence of euthyroidism (TSH and FT4 within their reference ranges) increased with longer duration of ATD in both groups; it was always higher in the T group than in the B + R group: 48 and 24%, respectively, at 6 months, 81 and 58% at 12 months, and 87 and 63% at 18 months (p < 0.002). There were no significant differences between the B + R and T regimens with respect to the fall in thyrotropin binding inhibiting immunoglobulins (TBII) or thyroid peroxidase antibodies (TPO-Ab). GO developed in 15.9% of all patients: 9.1 and 17.8% in B + R group and T group, respectively, (p = 0.096). GO was mild in 13% and moderate-to-severe in 2%. Conclusion: The prevalence of biochemical euthyroidism during treatment with antithyroid drugs is higher during T compared to B + R regimen. De novo development of GO did not differ significantly between the two regimens, although it tended to be higher in the T group. Whether one regimen is clinically more advantageous than the other remains unclear.

Original languageEnglish
Pages (from-to)371-378
JournalJournal of Endocrinological Investigation
Issue number2
Publication statusPublished - 2021


  • Antithyroid drugs
  • Graves’ disease treatment
  • Graves’ orbitopathy
  • Hyperthyroidism

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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