Antithrombotic Therapy in Patients Undergoing Transcatheter Interventions for Structural Heart Disease

Paolo Calabrò, Felice Gragnano, Giampaolo Niccoli, Rossella Marcucci, Marco Zimarino, Carmen Spaccarotella, Giulia Renda, Giuseppe Patti, Giuseppe Andò, Elisabetta Moscarella, Massimo Mancone, Arturo Cesaro, Gennaro Giustino, Raffaele De Caterina, Roxana Mehran, Davide Capodanno, Marco Valgimigli, Stephan Windecker, George D. Dangas, Ciro IndolfiDominick J. Angiolillo

Research output: Contribution to journalArticlepeer-review


Contemporary evidence supports device-based transcatheter interventions for the management of patients with structural heart disease. These procedures, which include aortic valve implantation, mitral or tricuspid valve repair/implantation, left atrial appendage occlusion, and patent foramen ovale closure, profoundly differ with respect to clinical indications and procedural aspects. Yet, patients undergoing transcatheter cardiac interventions require antithrombotic therapy before, during, or after the procedure to prevent thromboembolic events. However, these therapies are associated with an increased risk of bleeding complications. To date, challenges and controversies exist regarding balancing the risk of thrombotic and bleeding complications in these patients such that the optimal antithrombotic regimens to adopt in each specific procedure is still unclear. In this review, we summarize current evidence on antithrombotic therapies for device-based transcatheter interventions targeting structural heart disease and emphasize the importance of a tailored approach in these patients.

Original languageEnglish
Pages (from-to)1323-1343
Number of pages21
Issue number16
Publication statusPublished - Oct 19 2021


  • anticoagulants
  • atrial appendage
  • atrial fibrillation
  • foramen ovale, patent
  • mitral valve
  • thrombosis
  • transcatheter aortic valve replacement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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