Antiepileptic Drugs and Brain Tumor Patients

Leslie Ray; Marta Maschio; Herbert B. Newton

doi:10.1016/B978-0-12-417043-8.00013-4

Antiepileptic Drugs and Brain Tumor Patients

Leslie Ray, Marta Maschio, Herbert B. Newton

Istituto Regina Elena

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Epilepsy is a common complication of patients with primary and metastatic brain tumors. To date, there has been no significant reduction in seizure frequency with the use of prophylactic antiepileptic drugs (AEDs), except for use as surgical prophylaxis. However, once brain tumor-related epilepsy (BTRE) has been established, optimal treatment remains unknown. In addition, despite adequate therapeutic concentrations of AEDs, refractory seizures are often common. In this chapter, we will review the evidence for various AEDs in the context of brain tumor-related epilepsy (BTRE).

Original language	English
Title of host publication	Epilepsy and Brain Tumors
Publisher	Elsevier Inc.
Pages	195-205
Number of pages	11
ISBN (Print)	9780124171268, 9780124170438
DOIs	https://doi.org/10.1016/B978-0-12-417043-8.00013-4
Publication status	Published - Mar 4 2015

Keywords

Brain tumor-related epilepsy
Lacosamide
Levetiracetam
Oxcarbazepine
Pregabilin
Topiramate

ASJC Scopus subject areas

Medicine(all)
Neuroscience(all)

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10.1016/B978-0-12-417043-8.00013-4

Cite this

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AB - Epilepsy is a common complication of patients with primary and metastatic brain tumors. To date, there has been no significant reduction in seizure frequency with the use of prophylactic antiepileptic drugs (AEDs), except for use as surgical prophylaxis. However, once brain tumor-related epilepsy (BTRE) has been established, optimal treatment remains unknown. In addition, despite adequate therapeutic concentrations of AEDs, refractory seizures are often common. In this chapter, we will review the evidence for various AEDs in the context of brain tumor-related epilepsy (BTRE).

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KW - Oxcarbazepine

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KW - Topiramate

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ER -

Antiepileptic Drugs and Brain Tumor Patients

Abstract

Keywords

ASJC Scopus subject areas

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