Anti-β-adrenoceptors autoimmunity causing 'idiopathic' arrhythmias and cardiomyopathy

Donatella Brisinda; Anna Rita Sorbo; Angela Venuti; Maria Pia Ruggieri; Raffaele Manna; Peter Fenici; Gerd Wallukat; Johan Hoebeke; Andrea Frustaci; Riccardo Fenici

doi:10.1253/circj.CJ-11-1374

Anti-β-adrenoceptors autoimmunity causing 'idiopathic' arrhythmias and cardiomyopathy

Donatella Brisinda, Anna Rita Sorbo, Angela Venuti, Maria Pia Ruggieri, Raffaele Manna, Peter Fenici, Gerd Wallukat, Johan Hoebeke, Andrea Frustaci, Riccardo Fenici

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Background: To determine the prevalence of anti-β-adrenoceptors autoantibodies (aβAA) in patients with idiopathic arrhythmias (IA) and to assess whether aβAA are predictive markers for concealed cardiomyopathy in such patients. Methods and Results: Sixty-seven patients (group 1) with IA [25 supraventricular (SVA) and 42 ventricular (VA)]; 14 patients (group 2) with suspected cardiomyopathy, 12 patients with definite cardiomyopathy (group 3); and 19 healthy controls (group 4) were tested with an enzyme immunoassay, using synthetic peptides corresponding to the second extracellular loop of the human β1- and β2-adrenoceptors. Endomyocardial biopsy was performed in 29 patients. As compared with group 4 [3/19 (15.7%)], anti-β1-adrenoceptor autoantibodies (aβ1AA) were more frequent in group-1 patients [38/67 (56.7%; P

Original language	English
Pages (from-to)	1345-1353
Number of pages	9
Journal	Circulation Journal
Volume	76
Issue number	6
DOIs	https://doi.org/10.1253/circj.CJ-11-1374
Publication status	Published - Jun 2012

Keywords

β-adrenoceptors
Arrhythmia
Biopsy
Cardiomyopathy
Myocarditis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1253/circj.CJ-11-1374

Cite this

@article{5bfde0c64ea24a1590662ec3207a22c3,

title = "Anti-β-adrenoceptors autoimmunity causing 'idiopathic' arrhythmias and cardiomyopathy",

abstract = "Background: To determine the prevalence of anti-β-adrenoceptors autoantibodies (aβAA) in patients with idiopathic arrhythmias (IA) and to assess whether aβAA are predictive markers for concealed cardiomyopathy in such patients. Methods and Results: Sixty-seven patients (group 1) with IA [25 supraventricular (SVA) and 42 ventricular (VA)]; 14 patients (group 2) with suspected cardiomyopathy, 12 patients with definite cardiomyopathy (group 3); and 19 healthy controls (group 4) were tested with an enzyme immunoassay, using synthetic peptides corresponding to the second extracellular loop of the human β1- and β2-adrenoceptors. Endomyocardial biopsy was performed in 29 patients. As compared with group 4 [3/19 (15.7%)], anti-β1-adrenoceptor autoantibodies (aβ1AA) were more frequent in group-1 patients [38/67 (56.7%; P",

keywords = "β-adrenoceptors, Arrhythmia, Biopsy, Cardiomyopathy, Myocarditis",

author = "Donatella Brisinda and Sorbo, {Anna Rita} and Angela Venuti and Ruggieri, {Maria Pia} and Raffaele Manna and Peter Fenici and Gerd Wallukat and Johan Hoebeke and Andrea Frustaci and Riccardo Fenici",

year = "2012",

month = jun,

doi = "10.1253/circj.CJ-11-1374",

language = "English",

volume = "76",

pages = "1345--1353",

journal = "Circulation Journal",

issn = "1346-9843",

publisher = "Japanese Circulation Society",

number = "6",

}

TY - JOUR

T1 - Anti-β-adrenoceptors autoimmunity causing 'idiopathic' arrhythmias and cardiomyopathy

AU - Brisinda, Donatella

AU - Sorbo, Anna Rita

AU - Venuti, Angela

AU - Ruggieri, Maria Pia

AU - Manna, Raffaele

AU - Fenici, Peter

AU - Wallukat, Gerd

AU - Hoebeke, Johan

AU - Frustaci, Andrea

AU - Fenici, Riccardo

PY - 2012/6

Y1 - 2012/6

N2 - Background: To determine the prevalence of anti-β-adrenoceptors autoantibodies (aβAA) in patients with idiopathic arrhythmias (IA) and to assess whether aβAA are predictive markers for concealed cardiomyopathy in such patients. Methods and Results: Sixty-seven patients (group 1) with IA [25 supraventricular (SVA) and 42 ventricular (VA)]; 14 patients (group 2) with suspected cardiomyopathy, 12 patients with definite cardiomyopathy (group 3); and 19 healthy controls (group 4) were tested with an enzyme immunoassay, using synthetic peptides corresponding to the second extracellular loop of the human β1- and β2-adrenoceptors. Endomyocardial biopsy was performed in 29 patients. As compared with group 4 [3/19 (15.7%)], anti-β1-adrenoceptor autoantibodies (aβ1AA) were more frequent in group-1 patients [38/67 (56.7%; P

AB - Background: To determine the prevalence of anti-β-adrenoceptors autoantibodies (aβAA) in patients with idiopathic arrhythmias (IA) and to assess whether aβAA are predictive markers for concealed cardiomyopathy in such patients. Methods and Results: Sixty-seven patients (group 1) with IA [25 supraventricular (SVA) and 42 ventricular (VA)]; 14 patients (group 2) with suspected cardiomyopathy, 12 patients with definite cardiomyopathy (group 3); and 19 healthy controls (group 4) were tested with an enzyme immunoassay, using synthetic peptides corresponding to the second extracellular loop of the human β1- and β2-adrenoceptors. Endomyocardial biopsy was performed in 29 patients. As compared with group 4 [3/19 (15.7%)], anti-β1-adrenoceptor autoantibodies (aβ1AA) were more frequent in group-1 patients [38/67 (56.7%; P

KW - β-adrenoceptors

KW - Arrhythmia

KW - Biopsy

KW - Cardiomyopathy

KW - Myocarditis

UR - http://www.scopus.com/inward/record.url?scp=84861616189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861616189&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-11-1374

DO - 10.1253/circj.CJ-11-1374

M3 - Article

C2 - 22447021

AN - SCOPUS:84861616189

SN - 1346-9843

VL - 76

SP - 1345

EP - 1353

JO - Circulation Journal

JF - Circulation Journal

IS - 6

ER -

Anti-β-adrenoceptors autoimmunity causing 'idiopathic' arrhythmias and cardiomyopathy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this