Anti-oxidants show an anti-hypertensive effect in diabetic and hypertensive subjects

A. Ceriello, D. Giugliano, A. Quatraro, P. J. Lefebvre

Research output: Contribution to journalArticlepeer-review


1. In this study an acute anti-hypertensive effect of three anti-oxidant agents (vitamin C, thiopronine and glutathione) in hypertensive subjects and in both hypertensive and non-hypertensive diabetic patients is reported. 2. The anti-oxidants had no effect on blood pressure in healthy normal subjects at a dose of 6 mmol, but thiopronine and glutathione produced a significant hypotensive effect at a dose of 12 mmol. 3. These data suggest that anti-oxidants might have a dilatatory effect and that an imbalance of the nitric oxide-free radical interaction might facilitate the development of hypertension in humans.

Original languageEnglish
Pages (from-to)739-742
Number of pages4
JournalClinical Science
Issue number6
Publication statusPublished - 1991


  • Anti-oxidants
  • Dilatatory effect
  • Hypertension

ASJC Scopus subject areas

  • Medicine(all)


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