Anterior uveitis complicating zoledronic acid infusion

Annalisa Colucci, Giulio Modorati, Elisabetta Miserocchi, Federico Di Matteo, Paolo Rama

Research output: Contribution to journalArticlepeer-review


Zoledronic acid is the most effective treatment in patients with hypercalcemia secondary to malignancy; occasionally it can be related to ocular inflammation. We report a case of severe unilateral anterior uveitis following administration of intravenous zoledronic acid in a patient with frontal hyperostosis secondary to breast cancer. The patient developed anterior uveitis 24 hours after the administration of intravenous zoledronate. The patient was treated with topical prednisone and cycloplegic eye drops, with complete recovery after one month. This report shows that, on rare occasions, zoledronic acid can be a possible cause of acute anterior uveitis. Copyright Informa Healthcare 2009.

Original languageEnglish
Pages (from-to)267-268
Number of pages2
JournalOcular Immunology and Inflammation
Issue number4
Publication statusPublished - Aug 2009


  • Bisphosphonates
  • Breast cancer
  • Uveitis
  • Zoledronate

ASJC Scopus subject areas

  • Ophthalmology
  • Immunology and Allergy


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