Annuloaortic ectasia and giant cell arteritis

Sandro Gelsomino, Stefano Romagnoli, Franca Gori, Gabriella Nesi, Chiara Anichini, Carlo Sorbara, Pierluigi Stefàno, Gian Franco Gensini

Research output: Contribution to journalArticlepeer-review


Background. Thoracic aortic aneurysm, aortic dissection and aortic valve regurgitation have been widely described in patients with Horton disease, also known as giant cell arteritis. We present our midterm experience with patients with these features. Methods. A total of 386 cases of ascending aorta and aortic valve replacement performed for thoracic aortic aneurysm and aortic insufficiency between 1998 and 2004 were reviewed. Among them 10 cases of histopathologically confirmed GAA were identified. Patients were predominantly female (90%); the mean age was 74.5 ± 4.6 years. Results. Eight patients (80%) showed typical annuloaortic ectasia, leading to significant aortic valve regurgitation. These subjects underwent a Bentall operation. Two patients whose sinuses seemed undilated and macroscopically normal had separate valve graft replacement at first operation and underwent reoperation due to dilatation of the native sinuses. Eight patients had partial aortic arch replacement (hemiarch), and 1 underwent total arch replacement. Six-year survival was 0.9 ± 0.09; freedom from reoperation at 6 years was 0.77 ± 0.13. Conclusions. Annuloaortic ectasia is a common finding in giant cell arteritis. In patients with Horton disease, the aortic root should always be replaced regardless of macroscopic findings.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalAnnals of Thoracic Surgery
Issue number1
Publication statusPublished - Jul 2005

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery


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