ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome

Leonardo De Luca; Leonardo Bolognese; Marco Valgimigli; Roberto Ceravolo; Gian Battista Danzi; Emanuela Piccaluga; Serena Rakar; Alberto Cremonesi; Francesco Maria Bovenzi; R. Abbate; F. Andreotti; L. Bolognese; G. Biondi-Zoccai; F. M. Bovenz; D. Capodanno; R. Caporale; P. Capranzano; N. Carrabba; G. Casella; C. Cavallini; R. Ceravolo; P. Colombo; M. R. Conte; S. Cordone; A. Cremonesi; G. B. Danzi; M. Del Pinto; G. De Luca; L. De Luca; S. De Servi; E. Di Lorenzo; G. Di Pasquale; G. Esposito; R. Farina; A. Fiscella; D. Formigli; S. Galli; P. Giudice; G. Gonzi; C. Greco; N. B. Grieco; L. La Vecchia; M. Lazzari; C. Lettieri; M. Lettino; U. Limbruno; A. Lupi; A. Macchi; M. Marini; M. Marzilli; A. Montinaro; G. Musumeci; A. Navazio; Z. Olivari; L. Oltrona Visconti; J. A. Oreglia; F. Ottani; G. Parodi; G. Pasquetto; G. Patti; A. Perkan; G. P. Perna; E. Piccaluga; F. Piscione; F. Prati; S. Rakar; R. Ravasio; F. Ronco; R. Rossini; A. Rubboli; F. Saia; G. Sardella; G. Satullo; S. Savonitto; P. Sbarzaglia; G. Scorcu; N. Signore; G. Tarantini; P. Terrosu; L. Testa; M. Tubaro; S. Valente; M. Valgimigli; F. Varbella; M. Vatrano

doi:10.1093/eurheartj/suu030

ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome

Leonardo De Luca, Leonardo Bolognese, Marco Valgimigli, Roberto Ceravolo, Gian Battista Danzi, Emanuela Piccaluga, Serena Rakar, Alberto Cremonesi, Francesco Maria Bovenzi, R. Abbate, F. Andreotti, L. Bolognese, G. Biondi-Zoccai, F. M. Bovenz, D. Capodanno, R. Caporale, P. Capranzano, N. Carrabba, G. Casella, C. CavalliniR. Ceravolo, P. Colombo, M. R. Conte, S. Cordone, A. Cremonesi, G. B. Danzi, M. Del Pinto, G. De Luca, L. De Luca, S. De Servi, E. Di Lorenzo, G. Di Pasquale, G. Esposito, R. Farina, A. Fiscella, D. Formigli, S. Galli, P. Giudice, G. Gonzi, C. Greco, N. B. Grieco, L. La Vecchia, M. Lazzari, C. Lettieri, M. Lettino, U. Limbruno, A. Lupi, A. Macchi, M. Marini, M. Marzilli, A. Montinaro, G. Musumeci, A. Navazio, Z. Olivari, L. Oltrona Visconti, J. A. Oreglia, F. Ottani, G. Parodi, G. Pasquetto, G. Patti, A. Perkan, G. P. Perna, E. Piccaluga, F. Piscione, F. Prati, S. Rakar, R. Ravasio, F. Ronco, R. Rossini, A. Rubboli, F. Saia, G. Sardella, G. Satullo, S. Savonitto, P. Sbarzaglia, G. Scorcu, N. Signore, G. Tarantini, P. Terrosu, L. Testa, M. Tubaro, S. Valente, M. Valgimigli, F. Varbella, M. Vatrano

Research output: Contribution to journal › Article › peer-review

Abstract

Antiplatelet therapy is the cornerstone of the pharmacologic management of patients with acute coronary syndrome (ACS). Over the last years, several studies have evaluated old and new oral or intravenous antiplatelet agents in ACS patients. In particular, research was focused on assessing superiority of two novel platelet adenosine diphosphate (ADP) P2Y₁₂ receptor antagonists (i.e. prasugrel and ticagrelor) over clopidogrel. Several large randomized controlled trials have been undertaken in this setting and a wide variety of pre-specified and post hoc analyses are available that evaluated the potential benefits of novel antiplatelet therapies in different subsets of patients with ACS. The aim of this document is to review recent data on the use of current antiplatelet agents for in-hospital treatment of ACS patients. For each drug or class of drugs, strong evidence and/or areas of uncertainty that warrant further research are highlighted by examining 10 subgroups of patients with ACS.

Original language	English
Pages (from-to)	C2-C28
Journal	European Heart Journal, Supplement
Volume	16
DOIs	https://doi.org/10.1093/eurheartj/suu030
Publication status	Published - Dec 1 2014

Keywords

Acute coronary syndrome
Antiplatelet agents
Aspirin
Cangrelor
Clopidogrel
Prasugrel
Ticagrelor

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1093/eurheartj/suu030

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De Luca, L., Bolognese, L., Valgimigli, M., Ceravolo, R., Danzi, G. B., Piccaluga, E., Rakar, S., Cremonesi, A., Bovenzi, F. M., Abbate, R., Andreotti, F., Bolognese, L., Biondi-Zoccai, G., Bovenz, F. M., Capodanno, D., Caporale, R., Capranzano, P., Carrabba, N., Casella, G., ... Vatrano, M. (2014). ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome. European Heart Journal, Supplement, 16, C2-C28. https://doi.org/10.1093/eurheartj/suu030

De Luca, L, Bolognese, L, Valgimigli, M, Ceravolo, R, Danzi, GB, Piccaluga, E, Rakar, S, Cremonesi, A, Bovenzi, FM, Abbate, R, Andreotti, F, Bolognese, L, Biondi-Zoccai, G, Bovenz, FM, Capodanno, D, Caporale, R, Capranzano, P, Carrabba, N, Casella, G, Cavallini, C, Ceravolo, R, Colombo, P, Conte, MR, Cordone, S, Cremonesi, A, Danzi, GB, Del Pinto, M, De Luca, G, De Luca, L, De Servi, S, Di Lorenzo, E, Di Pasquale, G, Esposito, G, Farina, R, Fiscella, A, Formigli, D, Galli, S, Giudice, P, Gonzi, G, Greco, C, Grieco, NB, La Vecchia, L, Lazzari, M, Lettieri, C, Lettino, M, Limbruno, U, Lupi, A, Macchi, A, Marini, M, Marzilli, M, Montinaro, A, Musumeci, G, Navazio, A, Olivari, Z, Oltrona Visconti, L, Oreglia, JA, Ottani, F, Parodi, G, Pasquetto, G, Patti, G, Perkan, A, Perna, GP, Piccaluga, E, Piscione, F, Prati, F, Rakar, S, Ravasio, R, Ronco, F, Rossini, R, Rubboli, A, Saia, F, Sardella, G, Satullo, G, Savonitto, S, Sbarzaglia, P, Scorcu, G, Signore, N, Tarantini, G, Terrosu, P, Testa, L, Tubaro, M, Valente, S, Valgimigli, M, Varbella, F & Vatrano, M 2014, 'ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome', European Heart Journal, Supplement, vol. 16, pp. C2-C28. https://doi.org/10.1093/eurheartj/suu030

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title = "ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome",

abstract = "Antiplatelet therapy is the cornerstone of the pharmacologic management of patients with acute coronary syndrome (ACS). Over the last years, several studies have evaluated old and new oral or intravenous antiplatelet agents in ACS patients. In particular, research was focused on assessing superiority of two novel platelet adenosine diphosphate (ADP) P2Y12 receptor antagonists (i.e. prasugrel and ticagrelor) over clopidogrel. Several large randomized controlled trials have been undertaken in this setting and a wide variety of pre-specified and post hoc analyses are available that evaluated the potential benefits of novel antiplatelet therapies in different subsets of patients with ACS. The aim of this document is to review recent data on the use of current antiplatelet agents for in-hospital treatment of ACS patients. For each drug or class of drugs, strong evidence and/or areas of uncertainty that warrant further research are highlighted by examining 10 subgroups of patients with ACS.",

keywords = "Acute coronary syndrome, Antiplatelet agents, Aspirin, Cangrelor, Clopidogrel, Prasugrel, Ticagrelor",

author = "{De Luca}, Leonardo and Leonardo Bolognese and Marco Valgimigli and Roberto Ceravolo and Danzi, {Gian Battista} and Emanuela Piccaluga and Serena Rakar and Alberto Cremonesi and Bovenzi, {Francesco Maria} and R. Abbate and F. Andreotti and L. Bolognese and G. Biondi-Zoccai and Bovenz, {F. M.} and D. Capodanno and R. Caporale and P. Capranzano and N. Carrabba and G. Casella and C. Cavallini and R. Ceravolo and P. Colombo and Conte, {M. R.} and S. Cordone and A. Cremonesi and Danzi, {G. B.} and {Del Pinto}, M. and {De Luca}, G. and {De Luca}, L. and {De Servi}, S. and {Di Lorenzo}, E. and {Di Pasquale}, G. and G. Esposito and R. Farina and A. Fiscella and D. Formigli and S. Galli and P. Giudice and G. Gonzi and C. Greco and Grieco, {N. B.} and {La Vecchia}, L. and M. Lazzari and C. Lettieri and M. Lettino and U. Limbruno and A. Lupi and A. Macchi and M. Marini and M. Marzilli and A. Montinaro and G. Musumeci and A. Navazio and Z. Olivari and {Oltrona Visconti}, L. and Oreglia, {J. A.} and F. Ottani and G. Parodi and G. Pasquetto and G. Patti and A. Perkan and Perna, {G. P.} and E. Piccaluga and F. Piscione and F. Prati and S. Rakar and R. Ravasio and F. Ronco and R. Rossini and A. Rubboli and F. Saia and G. Sardella and G. Satullo and S. Savonitto and P. Sbarzaglia and G. Scorcu and N. Signore and G. Tarantini and P. Terrosu and L. Testa and M. Tubaro and S. Valente and M. Valgimigli and F. Varbella and M. Vatrano",

year = "2014",

month = dec,

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doi = "10.1093/eurheartj/suu030",

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T1 - ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome

AU - De Luca, Leonardo

AU - Bolognese, Leonardo

AU - Valgimigli, Marco

AU - Ceravolo, Roberto

AU - Danzi, Gian Battista

AU - Piccaluga, Emanuela

AU - Rakar, Serena

AU - Cremonesi, Alberto

AU - Bovenzi, Francesco Maria

AU - Abbate, R.

AU - Andreotti, F.

AU - Bolognese, L.

AU - Biondi-Zoccai, G.

AU - Bovenz, F. M.

AU - Capodanno, D.

AU - Caporale, R.

AU - Capranzano, P.

AU - Carrabba, N.

AU - Casella, G.

AU - Cavallini, C.

AU - Ceravolo, R.

AU - Colombo, P.

AU - Conte, M. R.

AU - Cordone, S.

AU - Cremonesi, A.

AU - Danzi, G. B.

AU - Del Pinto, M.

AU - De Luca, G.

AU - De Luca, L.

AU - De Servi, S.

AU - Di Lorenzo, E.

AU - Di Pasquale, G.

AU - Esposito, G.

AU - Farina, R.

AU - Fiscella, A.

AU - Formigli, D.

AU - Galli, S.

AU - Giudice, P.

AU - Gonzi, G.

AU - Greco, C.

AU - Grieco, N. B.

AU - La Vecchia, L.

AU - Lazzari, M.

AU - Lettieri, C.

AU - Lettino, M.

AU - Limbruno, U.

AU - Lupi, A.

AU - Macchi, A.

AU - Marini, M.

AU - Marzilli, M.

AU - Montinaro, A.

AU - Musumeci, G.

AU - Navazio, A.

AU - Olivari, Z.

AU - Oltrona Visconti, L.

AU - Oreglia, J. A.

AU - Ottani, F.

AU - Parodi, G.

AU - Pasquetto, G.

AU - Patti, G.

AU - Perkan, A.

AU - Perna, G. P.

AU - Piccaluga, E.

AU - Piscione, F.

AU - Prati, F.

AU - Rakar, S.

AU - Ravasio, R.

AU - Ronco, F.

AU - Rossini, R.

AU - Rubboli, A.

AU - Saia, F.

AU - Sardella, G.

AU - Satullo, G.

AU - Savonitto, S.

AU - Sbarzaglia, P.

AU - Scorcu, G.

AU - Signore, N.

AU - Tarantini, G.

AU - Terrosu, P.

AU - Testa, L.

AU - Tubaro, M.

AU - Valente, S.

AU - Valgimigli, M.

AU - Varbella, F.

AU - Vatrano, M.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Antiplatelet therapy is the cornerstone of the pharmacologic management of patients with acute coronary syndrome (ACS). Over the last years, several studies have evaluated old and new oral or intravenous antiplatelet agents in ACS patients. In particular, research was focused on assessing superiority of two novel platelet adenosine diphosphate (ADP) P2Y12 receptor antagonists (i.e. prasugrel and ticagrelor) over clopidogrel. Several large randomized controlled trials have been undertaken in this setting and a wide variety of pre-specified and post hoc analyses are available that evaluated the potential benefits of novel antiplatelet therapies in different subsets of patients with ACS. The aim of this document is to review recent data on the use of current antiplatelet agents for in-hospital treatment of ACS patients. For each drug or class of drugs, strong evidence and/or areas of uncertainty that warrant further research are highlighted by examining 10 subgroups of patients with ACS.

AB - Antiplatelet therapy is the cornerstone of the pharmacologic management of patients with acute coronary syndrome (ACS). Over the last years, several studies have evaluated old and new oral or intravenous antiplatelet agents in ACS patients. In particular, research was focused on assessing superiority of two novel platelet adenosine diphosphate (ADP) P2Y12 receptor antagonists (i.e. prasugrel and ticagrelor) over clopidogrel. Several large randomized controlled trials have been undertaken in this setting and a wide variety of pre-specified and post hoc analyses are available that evaluated the potential benefits of novel antiplatelet therapies in different subsets of patients with ACS. The aim of this document is to review recent data on the use of current antiplatelet agents for in-hospital treatment of ACS patients. For each drug or class of drugs, strong evidence and/or areas of uncertainty that warrant further research are highlighted by examining 10 subgroups of patients with ACS.

KW - Acute coronary syndrome

KW - Antiplatelet agents

KW - Aspirin

KW - Cangrelor

KW - Clopidogrel

KW - Prasugrel

KW - Ticagrelor

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DO - 10.1093/eurheartj/suu030

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VL - 16

SP - C2-C28

JO - European Heart Journal, Supplement

JF - European Heart Journal, Supplement

ER -

ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome

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Keywords

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