ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome

Leonardo De Luca, Leonardo Bolognese, Marco Valgimigli, Roberto Ceravolo, Gian Battista Danzi, Emanuela Piccaluga, Serena Rakar, Alberto Cremonesi, Francesco Maria Bovenzi, R. Abbate, F. Andreotti, L. Bolognese, G. Biondi-Zoccai, F. M. Bovenz, D. Capodanno, R. Caporale, P. Capranzano, N. Carrabba, G. Casella, C. CavalliniR. Ceravolo, P. Colombo, M. R. Conte, S. Cordone, A. Cremonesi, G. B. Danzi, M. Del Pinto, G. De Luca, L. De Luca, S. De Servi, E. Di Lorenzo, G. Di Pasquale, G. Esposito, R. Farina, A. Fiscella, D. Formigli, S. Galli, P. Giudice, G. Gonzi, C. Greco, N. B. Grieco, L. La Vecchia, M. Lazzari, C. Lettieri, M. Lettino, U. Limbruno, A. Lupi, A. Macchi, M. Marini, M. Marzilli, A. Montinaro, G. Musumeci, A. Navazio, Z. Olivari, L. Oltrona Visconti, J. A. Oreglia, F. Ottani, G. Parodi, G. Pasquetto, G. Patti, A. Perkan, G. P. Perna, E. Piccaluga, F. Piscione, F. Prati, S. Rakar, R. Ravasio, F. Ronco, R. Rossini, A. Rubboli, F. Saia, G. Sardella, G. Satullo, S. Savonitto, P. Sbarzaglia, G. Scorcu, N. Signore, G. Tarantini, P. Terrosu, L. Testa, M. Tubaro, S. Valente, M. Valgimigli, F. Varbella, M. Vatrano

Research output: Contribution to journalArticlepeer-review


Antiplatelet therapy is the cornerstone of the pharmacologic management of patients with acute coronary syndrome (ACS). Over the last years, several studies have evaluated old and new oral or intravenous antiplatelet agents in ACS patients. In particular, research was focused on assessing superiority of two novel platelet adenosine diphosphate (ADP) P2Y12 receptor antagonists (i.e. prasugrel and ticagrelor) over clopidogrel. Several large randomized controlled trials have been undertaken in this setting and a wide variety of pre-specified and post hoc analyses are available that evaluated the potential benefits of novel antiplatelet therapies in different subsets of patients with ACS. The aim of this document is to review recent data on the use of current antiplatelet agents for in-hospital treatment of ACS patients. For each drug or class of drugs, strong evidence and/or areas of uncertainty that warrant further research are highlighted by examining 10 subgroups of patients with ACS.

Original languageEnglish
Pages (from-to)C2-C28
JournalEuropean Heart Journal, Supplement
Publication statusPublished - Dec 1 2014


  • Acute coronary syndrome
  • Antiplatelet agents
  • Aspirin
  • Cangrelor
  • Clopidogrel
  • Prasugrel
  • Ticagrelor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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