TY - JOUR
T1 - Animal models of medullary thyroid cancer
T2 - State of the art and view to the future
AU - Vitale, Giovanni
AU - Gaudenzi, Germano
AU - Circelli, Luisa
AU - Manzoni, Marco F.
AU - Bassi, Andrea
AU - Fioritti, Niccolò
AU - Faggiano, Antongiulio
AU - Colao, Annamaria
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Medullary thyroid carcinoma is a neuroendocrine tumour originating from parafollicular C cells accounting for 5-10% of thyroid cancers. Increased understanding of diseasespecific molecular targets of therapy has led to the regulatory approval of two drugs (vandetanib and cabozantinib) for the treatment of medullary thyroid carcinoma. These drugs increase progression-free survival; however, they are often poorly tolerated and most treatment responses are transient. Animal models are indispensable tools for investigating the pathogenesis, mechanisms for tumour invasion and metastasis and new therapeutic approaches for cancer. Unfortunately, only few models are available for medullary thyroid carcinoma. This review provides an overview of the state of the art of animal models in medullary thyroid carcinoma and highlights future developments in this field, with the aim of addressing salient features and clinical relevance.
AB - Medullary thyroid carcinoma is a neuroendocrine tumour originating from parafollicular C cells accounting for 5-10% of thyroid cancers. Increased understanding of diseasespecific molecular targets of therapy has led to the regulatory approval of two drugs (vandetanib and cabozantinib) for the treatment of medullary thyroid carcinoma. These drugs increase progression-free survival; however, they are often poorly tolerated and most treatment responses are transient. Animal models are indispensable tools for investigating the pathogenesis, mechanisms for tumour invasion and metastasis and new therapeutic approaches for cancer. Unfortunately, only few models are available for medullary thyroid carcinoma. This review provides an overview of the state of the art of animal models in medullary thyroid carcinoma and highlights future developments in this field, with the aim of addressing salient features and clinical relevance.
KW - Animal models
KW - Chick chorioallantoic membrane
KW - Drosophila melanogaster
KW - Medullary thyroid cancer
KW - Mice
KW - Zebrafish
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U2 - 10.1530/ERC-16-0399
DO - 10.1530/ERC-16-0399
M3 - Review article
AN - SCOPUS:85010698095
SN - 1351-0088
VL - 24
SP - R1-R12
JO - Endocrine-Related Cancer
JF - Endocrine-Related Cancer
IS - 1
ER -