Angiogenesis in acute and chronic lymphocytic leukemia

Stefano Molica; Angelo Vacca; Domenico Levato; Francesca Merchionne; Domenico Ribatti

doi:10.1016/j.leukres.2003.08.001

Angiogenesis in acute and chronic lymphocytic leukemia

Stefano Molica, Angelo Vacca, Domenico Levato, Francesca Merchionne, Domenico Ribatti

IRCCS Giovanni Paolo II

Research output: Contribution to journal › Article › peer-review

Abstract

The bone marrow microenvironment plays a crucial role in leukemogenesis. Recent studies suggest that its vascularity changes significantly during this process and that angiogenic factors are of major importance in leukemia. This review summarizes the literature concerning the relationship between angiogenesis and the progression of acute and chronic lymphocytic leukemia. It is becoming increasingly evident that agents which interfere with angiogenesis also block tumor progression and anti-angiogenic management has become a prominent aspect of pre-clinical and clinical assessment. Recent applications of anti-angiogenic agents which interfere with or block leukemia progression are reviewed.

Original language	English
Pages (from-to)	321-324
Number of pages	4
Journal	Leukemia Research
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.leukres.2003.08.001
Publication status	Published - Apr 2004

Keywords

ALL
Angiogenesis
Clinical significance
CLL

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

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10.1016/j.leukres.2003.08.001

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AU - Molica, Stefano

AU - Vacca, Angelo

AU - Levato, Domenico

AU - Merchionne, Francesca

AU - Ribatti, Domenico

PY - 2004/4

Y1 - 2004/4

N2 - The bone marrow microenvironment plays a crucial role in leukemogenesis. Recent studies suggest that its vascularity changes significantly during this process and that angiogenic factors are of major importance in leukemia. This review summarizes the literature concerning the relationship between angiogenesis and the progression of acute and chronic lymphocytic leukemia. It is becoming increasingly evident that agents which interfere with angiogenesis also block tumor progression and anti-angiogenic management has become a prominent aspect of pre-clinical and clinical assessment. Recent applications of anti-angiogenic agents which interfere with or block leukemia progression are reviewed.

AB - The bone marrow microenvironment plays a crucial role in leukemogenesis. Recent studies suggest that its vascularity changes significantly during this process and that angiogenic factors are of major importance in leukemia. This review summarizes the literature concerning the relationship between angiogenesis and the progression of acute and chronic lymphocytic leukemia. It is becoming increasingly evident that agents which interfere with angiogenesis also block tumor progression and anti-angiogenic management has become a prominent aspect of pre-clinical and clinical assessment. Recent applications of anti-angiogenic agents which interfere with or block leukemia progression are reviewed.

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KW - Angiogenesis

KW - Clinical significance

KW - CLL

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Angiogenesis in acute and chronic lymphocytic leukemia

Abstract

Keywords

ASJC Scopus subject areas

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