Analysis of progression of reticular pseudodrusen by spectral domain-optical coherence tomography

Giuseppe Querques, Florence Canouï-Poitrine, Florence Coscas, Nathalie Massamba, Lea Querques, Gerard Mimoun, Francesco Bandello, Eric H. Souied

Research output: Contribution to journalArticlepeer-review


PURPOSE. To analyze reticular pseudodrusen progression using spectral domain-optical coherence tomography (SD-OCT). METHODS. Thirty-three consecutive patients (48 eyes) underwent SD-OCT using the eye-tracked follow-up protocol 24 ± 2 months after baseline examination. Each pair of B-scans (only one per eye was evaluated among those showing pseudodrusen progression) was compared with respect to pseudodrusen appearance and retinal layer structure. Stage 1 pseudodrusen was defined as granular material between the RPE and the inner segment/outer segment (IS/OS), stage 2 as mounds of material sufficient to alter the contour of the IS/OS, stage 3 as thicker material adopting a conical appearance and breaking through the IS/OS, and stage 4 as fading of the material because of reabsorption and migration within the inner retinal layers. RESULTS. A total of 78 pseudodrusen (detected on the 48 analyzed B-scans, and counting for a mean of 2.3 pseudodrusen per scan) showed progression over a mean of 23.9 ± 1.2 months. All 58 pseudodrusen (100%) graded as stage 1 at baseline examination progressed to stage 2. Thirteen of 16 pseudodrusen (81.3%) graded as stage 2 at baseline examination progressed to stage 3, and three (18.7%) progressed to stage 4. All four pseudodrusen (100%) graded as stage 3 at baseline examination progressed to stage 4. Among pseudodrusen that were stage 3 or 4 at follow-up (n = 20), 100% had IS/OS disruption whereas 12.1% (n = 7) had IS/OS disruption at stage 1 or 2 (n = 58) (OR, 1.736; 95% CI, 1.02-2.43). CONCLUSIONS. The frequency of stage changes over time suggest that reticular pseudodrusen are dynamic pathologic structures.

Original languageEnglish
Pages (from-to)1264-1270
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Issue number3
Publication statusPublished - Mar 2012

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)


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