TY - JOUR
T1 - An overview on the potential roles of egcg in the treatment of covid-19 infection
AU - Bimonte, Sabrina
AU - Forte, Cira Antonietta
AU - Cuomo, Massimiliano
AU - Esposito, Gennaro
AU - Cascella, Marco
AU - Cuomo, Arturo
N1 - Funding Information:
We are grateful to Dr. Alessandra Trocino and Mrs. Cristina Romano from the National Cancer Institute of Naples for providing excellent bibliographic service and assistance. Sabrina Bimonte and Cira Antonietta Forte are co-first authors of this study. Marco Cascella and Arturo Cuomo are co-last authors of this study.
Publisher Copyright:
© 2021 Bimonte et al.
PY - 2021
Y1 - 2021
N2 - Coronavirus disease-19 (COVID-19) pandemic is currently ongoing worldwide and causes a lot of deaths in many countries. Although different vaccines for the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection have been developed and are now available, there are no effective antiviral drugs to treat the disease, except for Remdesivir authorized by the US FDA to counteract the emergency. Thus, it can be useful to find alternative therapies based on the employment of natural compounds, with antiviral features, to circumvent SARS-CoV-2 infection. Pre-clinical studies highlighted the antiviral activities of epigallocatechin-3-gallate (EGCG), a catechin primarily found in green tea, against various viruses, including SARS-CoV-2. In this review, we summarize this experi-mental evidence and highlight the potential use of EGCG as an alternative therapeutic choice for the treatment of SARS-CoV-2 infection.
AB - Coronavirus disease-19 (COVID-19) pandemic is currently ongoing worldwide and causes a lot of deaths in many countries. Although different vaccines for the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection have been developed and are now available, there are no effective antiviral drugs to treat the disease, except for Remdesivir authorized by the US FDA to counteract the emergency. Thus, it can be useful to find alternative therapies based on the employment of natural compounds, with antiviral features, to circumvent SARS-CoV-2 infection. Pre-clinical studies highlighted the antiviral activities of epigallocatechin-3-gallate (EGCG), a catechin primarily found in green tea, against various viruses, including SARS-CoV-2. In this review, we summarize this experi-mental evidence and highlight the potential use of EGCG as an alternative therapeutic choice for the treatment of SARS-CoV-2 infection.
KW - Antiviral properties
KW - COVID-19
KW - EGCG
KW - SARS-CoV-2
KW - Tea polyphenols
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U2 - 10.2147/DDDT.S314666
DO - 10.2147/DDDT.S314666
M3 - Review article
AN - SCOPUS:85118246652
SN - 1177-8881
VL - 15
SP - 4447
EP - 4454
JO - Drug Design, Development and Therapy
JF - Drug Design, Development and Therapy
ER -