An epidemiological study of the clinical impact of pharmacokinetic anticonvulsant drug interactions based on serum drug level analysis

F. Pisani; A. Fazio; C. Artesi; G. Oteri; B. Pisani; F. Romano; E. Perucca; R. Di Perri

doi:10.1007/BF02337587

An epidemiological study of the clinical impact of pharmacokinetic anticonvulsant drug interactions based on serum drug level analysis

F. Pisani, A. Fazio, C. Artesi, G. Oteri, B. Pisani, F. Romano, E. Perucca, R. Di Perri

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

The impact of pharmacokinetic anticonvulsant drug interactions on prescribing patterns and serum drug level distribution in a routine clinical setting was evaluated in a population of 848 patients chronically treated with phenytoin, phenobarbital, carbamazepine and valproic acid (either alone or as two-drug combinations) and referred for therapeutic drug monitoring for the first time. While dosages of each drug did not differ significantly between monotherapy and polytherapy patients, significant differences in serum level distribution were found. The proportion of patients with suboptimal serum carbamazepine and valproic acid levels (

Original language	English
Pages (from-to)	135-141
Number of pages	7
Journal	Italian Journal of Neurological Sciences
Volume	8
Issue number	2
DOIs	https://doi.org/10.1007/BF02337587
Publication status	Published - Apr 1987

Keywords

Antiepiletic drug interation
Clinical
Epidemiology
Impact

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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10.1007/BF02337587

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abstract = "The impact of pharmacokinetic anticonvulsant drug interactions on prescribing patterns and serum drug level distribution in a routine clinical setting was evaluated in a population of 848 patients chronically treated with phenytoin, phenobarbital, carbamazepine and valproic acid (either alone or as two-drug combinations) and referred for therapeutic drug monitoring for the first time. While dosages of each drug did not differ significantly between monotherapy and polytherapy patients, significant differences in serum level distribution were found. The proportion of patients with suboptimal serum carbamazepine and valproic acid levels (",

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author = "F. Pisani and A. Fazio and C. Artesi and G. Oteri and B. Pisani and F. Romano and E. Perucca and {Di Perri}, R.",

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AU - Pisani, F.

AU - Fazio, A.

AU - Artesi, C.

AU - Oteri, G.

AU - Pisani, B.

AU - Romano, F.

AU - Perucca, E.

AU - Di Perri, R.

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KW - Impact

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An epidemiological study of the clinical impact of pharmacokinetic anticonvulsant drug interactions based on serum drug level analysis

Abstract

Keywords

ASJC Scopus subject areas

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