An electrophysiological study of visual processing in Alzheimer's disease

Gastone G. Celesia, Alessandro E P Villa, Mitchell Brigell, Guido Rubboli, Gastone Bolcioni, Mario G. Fiori

Research output: Contribution to journalArticlepeer-review


Visual processing of sinusoidally modulated gratings was studied in a group of patients (n = 11) with Alzheimer's disease (AD) and an elderly normal control group (n = 9). Spatial square wave gratings (1.47 c/d) were reversed at a temporal frequency of 4 or 8 Hz. EEG recordings at rest and during visual stimulation were obtained from 20 channels using the 10/20 international system. The power spectrum of the 2nd and 4th harmonic of the stimulation frequency was calculated by Fast Fourier Transform (FFT) at a resolution of 0.25 Hz. Association of activity between occipital, temporal, parietal and central regions was measured by intra- and inter-hemispheric coherence and phase at harmonics of the stimulation frequency. A significant difference (P

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalElectroencephalography and Clinical Neurophysiology
Issue number3
Publication statusPublished - 1993


  • Alzheimer's disease
  • EEG
  • Intra-hemispheric coherence
  • Visual dysfunction
  • Visual stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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