Amniocentesis and chorionic villus sampling in HIV-infected pregnant women: a multicentre case series

M. Floridia, G. Masuelli, M. A. Meloni, I. Cetin, E. Tamburrini, A. F. Cavaliere, S. Dalzero, M. Sansone, S Alberico, B. Guerra, A Spinillo, Michela Chiadò Fiorio Tin, M. Ravizza, Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy, Alessandro Capone, Carmela Pinnetti, Giuseppina Liuzzi

Research output: Contribution to journalArticlepeer-review


OBJECTIVES: To assess in pregnant women with HIV the rates of amniocentesis and chorionic villus sampling (CVS), and the outcomes associated with such procedures.

DESIGN: Observational study. Data from the Italian National Program on Surveillance on Antiretroviral Treatment in Pregnancy were used.

SETTING: University and hospital clinics.

POPULATION: Pregnant women with HIV.

METHODS: Temporal trends were analysed by analysis of variance and by the Chi-square test for trend. Quantitative variables were compared by Student's t-test and categorical data by the Chi-square test, with odds ratios and 95% confidence intervals calculated.

MAIN OUTCOME MEASURES: Rate of invasive testing, intrauterine death, HIV transmission.

RESULTS: Between 2001 and 2015, among 2065 pregnancies in women with HIV, 113 (5.5%) had invasive tests performed. The procedures were conducted under antiretroviral treatment in 99 cases (87.6%), with a significant increase over time in the proportion of tests performed under highly active antiretroviral therapy (HAART) (100% in 2011-2015). Three intrauterine deaths were observed (2.6%), and 14 pregnancies were terminated because of fetal anomalies. Among 96 live newborns, eight had no information available on HIV status. Among the remaining 88 cases with either amniocentesis (n = 75), CVS (n = 12), or both (n = 1), two HIV transmissions occurred (2.3%). No HIV transmission occurred among the women who were on HAART at the time of invasive testing, and none after 2005.

CONCLUSIONS: The findings reinforce the assumption that invasive prenatal testing does not increase the risk of HIV vertical transmission among pregnant women under suppressive antiretroviral treatment.

TWEETABLE ABSTRACT: No HIV transmission occurred among women who underwent amniocentesis or CVS under effective anti-HIV regimens.

Original languageEnglish
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Publication statusE-pub ahead of print - Jun 20 2016


  • Journal Article


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