TY - JOUR
T1 - Altered Taste Function in Young Individuals With Type 1 Diabetes
AU - Catamo, Eulalia
AU - Robino, Antonietta
AU - Tinti, Davide
AU - Dovc, Klemen
AU - Franceschi, Roberto
AU - Giangreco, Manuela
AU - Gasparini, Paolo
AU - Barbi, Egidio
AU - Cauvin, Vittoria
AU - Rabbone, Ivana
AU - Battelino, Tadej
AU - Tornese, Gianluca
N1 - Funding Information:
This work was supported by ISPAD-JDRF Fellowship 2017 and Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy (RC 14/16) to GT, and by Italian Ministry of Health (GR-2019-12369573) to AR. KD and TB were supported in part by the Slovenian Research Agency Grant P3-0343.
Publisher Copyright:
Copyright © 2022 Catamo, Robino, Tinti, Dovc, Franceschi, Giangreco, Gasparini, Barbi, Cauvin, Rabbone, Battelino and Tornese.
PY - 2022/1/12
Y1 - 2022/1/12
N2 - Past studies on altered taste function in individuals with type 1 diabetes have yielded inconsistent results. We therefore evaluated taste recognition and possible association with personal and diseases characteristics in young individuals with type 1 diabetes and healthy controls. Taste recognition and intensity for 6-n-propylthiouracil (PROP), quinine, citric acid, sucrose, and sodium chloride were assessed using a filter paper method in 276 participants with type 1 diabetes and 147 healthy controls. Personal and clinical data were recorded for all participants during a baseline visit. Regression analysis was adjusted for sex, age, and standardized BMI. Overall, 47% of participants with type 1 diabetes vs. 63.5% of healthy controls recognized all tastes (p = 0.006). Moreover, a lower capacity for recognizing the bitter taste of PROP and the sour taste of citric acid was found in participants with type 1 diabetes compared to healthy controls (p = 0.014 and p = 0.003, respectively). While no significant effect of glycemic control on taste recognition was found, an association with lower age at onset emerged. Our findings suggest an impaired taste perception in individuals with type 1 diabetes, possibly linked to age at onset.
AB - Past studies on altered taste function in individuals with type 1 diabetes have yielded inconsistent results. We therefore evaluated taste recognition and possible association with personal and diseases characteristics in young individuals with type 1 diabetes and healthy controls. Taste recognition and intensity for 6-n-propylthiouracil (PROP), quinine, citric acid, sucrose, and sodium chloride were assessed using a filter paper method in 276 participants with type 1 diabetes and 147 healthy controls. Personal and clinical data were recorded for all participants during a baseline visit. Regression analysis was adjusted for sex, age, and standardized BMI. Overall, 47% of participants with type 1 diabetes vs. 63.5% of healthy controls recognized all tastes (p = 0.006). Moreover, a lower capacity for recognizing the bitter taste of PROP and the sour taste of citric acid was found in participants with type 1 diabetes compared to healthy controls (p = 0.014 and p = 0.003, respectively). While no significant effect of glycemic control on taste recognition was found, an association with lower age at onset emerged. Our findings suggest an impaired taste perception in individuals with type 1 diabetes, possibly linked to age at onset.
KW - age at onset
KW - glycemic control
KW - pediatric samples
KW - taste function
KW - type 1 diabetes
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U2 - 10.3389/fnut.2021.797920
DO - 10.3389/fnut.2021.797920
M3 - Article
AN - SCOPUS:85123407305
SN - 2296-861X
VL - 8
JO - Frontiers in Nutrition
JF - Frontiers in Nutrition
M1 - 797920
ER -