Altered lipid composition and thromboxane A2 formation in platelets from patients affected by IIa hyperlipoproteinemia

Domenico Prisco; Pier Giorgio Rogasi; Rita Paniccia; Mirella Coppo; Rosanna Abbate; Gian Franco Gensini; Gian Gastone Neri Serneri

doi:10.1016/0049-3848(88)90318-0

Altered lipid composition and thromboxane A2 formation in platelets from patients affected by IIa hyperlipoproteinemia

Domenico Prisco, Pier Giorgio Rogasi, Rita Paniccia, Mirella Coppo, Rosanna Abbate, Gian Franco Gensini, Gian Gastone Neri Serneri

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Platelets from patients with familial hypercholesterolemia (type IIa hyperlipoproteinemia), a condition associated with high prevalence of atherosclerosis and of its thrombotic complications, are known to be hyperresponsive to aggregating stimuli and to synthesize increased amounts of thromboxane A2 (TxA2) in comparison to platelets from normal subjects. In order to search if these functional alterations are linked to a different platelet lipid composition, we studied a group of young patients affected by IIa hyperlipoproteinemia and a group of suitable controls with similar dietary habits. Both cholesterol and phospholipid content of platelets were higher in patients than in controls with a significant increase of cholesterol/phospholipid molar ratio (at least p

Original language	English
Pages (from-to)	593-604
Number of pages	12
Journal	Thrombosis Research
Volume	50
Issue number	5
DOIs	https://doi.org/10.1016/0049-3848(88)90318-0
Publication status	Published - Jun 1 1988

Keywords

cholesterol
IIa hyperlipoproteinemia
phospholipids
Platelets lipids
saturated fatty acids
thromboxane A2

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Hematology

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10.1016/0049-3848(88)90318-0

Cite this

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title = "Altered lipid composition and thromboxane A2 formation in platelets from patients affected by IIa hyperlipoproteinemia",

abstract = "Platelets from patients with familial hypercholesterolemia (type IIa hyperlipoproteinemia), a condition associated with high prevalence of atherosclerosis and of its thrombotic complications, are known to be hyperresponsive to aggregating stimuli and to synthesize increased amounts of thromboxane A2 (TxA2) in comparison to platelets from normal subjects. In order to search if these functional alterations are linked to a different platelet lipid composition, we studied a group of young patients affected by IIa hyperlipoproteinemia and a group of suitable controls with similar dietary habits. Both cholesterol and phospholipid content of platelets were higher in patients than in controls with a significant increase of cholesterol/phospholipid molar ratio (at least p",

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AU - Prisco, Domenico

AU - Rogasi, Pier Giorgio

AU - Paniccia, Rita

AU - Coppo, Mirella

AU - Abbate, Rosanna

AU - Gensini, Gian Franco

AU - Serneri, Gian Gastone Neri

PY - 1988/6/1

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Altered lipid composition and thromboxane A2 formation in platelets from patients affected by IIa hyperlipoproteinemia

Abstract

Keywords

ASJC Scopus subject areas

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