Altered expression of HLA-A,B specificities on acute lymphoid and myeloid leukaemia blasts

C. Pozzi; D. Peruccio; A. M. Dall'Omo; S. D'Alfonso; P. Savoia; M. G. Guerra; R. Miniero; M. Lecchi; L. Resegotti; P. Richiardi

Altered expression of HLA-A,B specificities on acute lymphoid and myeloid leukaemia blasts

C. Pozzi, D. Peruccio, A. M. Dall'Omo, S. D'Alfonso, P. Savoia, M. G. Guerra, R. Miniero, M. Lecchi, L. Resegotti, P. Richiardi

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

HLA-A,B specificities were analysed on the neoplastic blasts of a panel of 69 lymphoblastic (ALL) and 50 non lymphoblastic (ANLL) acute leukaemias at onset using the standard lymphocytotoxicity technique. Analysis of the number of detected specificities per locus and, when possible, comparison of the results with those obtained on lymphocytes of the same patients during remission revealed many alterations in the expression of A,B specificities including extra specificities both at the HLA-A and -B loci mainly on lymphoblasts and missed specificities mainly at the HLA-B locus on myeloblasts. Lack of A,B antigens was complete in 6.2% of all tested samples (9% of ANLL) and selective for all the products of one locus in 16.8% of all tested samples (27.7% of ANLL). A decrease of class I molecules on the cell surface was evidenced with MoAb W6/32 on blasts missing detectable serological specificities.

Original language	English
Pages (from-to)	161-168
Number of pages	8
Journal	Journal of Immunogenetics
Volume	17
Issue number	3
Publication status	Published - 1990

ASJC Scopus subject areas

Immunology
Genetics

Cite this

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title = "Altered expression of HLA-A,B specificities on acute lymphoid and myeloid leukaemia blasts",

abstract = "HLA-A,B specificities were analysed on the neoplastic blasts of a panel of 69 lymphoblastic (ALL) and 50 non lymphoblastic (ANLL) acute leukaemias at onset using the standard lymphocytotoxicity technique. Analysis of the number of detected specificities per locus and, when possible, comparison of the results with those obtained on lymphocytes of the same patients during remission revealed many alterations in the expression of A,B specificities including extra specificities both at the HLA-A and -B loci mainly on lymphoblasts and missed specificities mainly at the HLA-B locus on myeloblasts. Lack of A,B antigens was complete in 6.2% of all tested samples (9% of ANLL) and selective for all the products of one locus in 16.8% of all tested samples (27.7% of ANLL). A decrease of class I molecules on the cell surface was evidenced with MoAb W6/32 on blasts missing detectable serological specificities.",

author = "C. Pozzi and D. Peruccio and Dall'Omo, {A. M.} and S. D'Alfonso and P. Savoia and Guerra, {M. G.} and R. Miniero and M. Lecchi and L. Resegotti and P. Richiardi",

year = "1990",

language = "English",

volume = "17",

pages = "161--168",

journal = "Journal of Immunogenetics",

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TY - JOUR

T1 - Altered expression of HLA-A,B specificities on acute lymphoid and myeloid leukaemia blasts

AU - Pozzi, C.

AU - Peruccio, D.

AU - Dall'Omo, A. M.

AU - D'Alfonso, S.

AU - Savoia, P.

AU - Guerra, M. G.

AU - Miniero, R.

AU - Lecchi, M.

AU - Resegotti, L.

AU - Richiardi, P.

PY - 1990

Y1 - 1990

N2 - HLA-A,B specificities were analysed on the neoplastic blasts of a panel of 69 lymphoblastic (ALL) and 50 non lymphoblastic (ANLL) acute leukaemias at onset using the standard lymphocytotoxicity technique. Analysis of the number of detected specificities per locus and, when possible, comparison of the results with those obtained on lymphocytes of the same patients during remission revealed many alterations in the expression of A,B specificities including extra specificities both at the HLA-A and -B loci mainly on lymphoblasts and missed specificities mainly at the HLA-B locus on myeloblasts. Lack of A,B antigens was complete in 6.2% of all tested samples (9% of ANLL) and selective for all the products of one locus in 16.8% of all tested samples (27.7% of ANLL). A decrease of class I molecules on the cell surface was evidenced with MoAb W6/32 on blasts missing detectable serological specificities.

AB - HLA-A,B specificities were analysed on the neoplastic blasts of a panel of 69 lymphoblastic (ALL) and 50 non lymphoblastic (ANLL) acute leukaemias at onset using the standard lymphocytotoxicity technique. Analysis of the number of detected specificities per locus and, when possible, comparison of the results with those obtained on lymphocytes of the same patients during remission revealed many alterations in the expression of A,B specificities including extra specificities both at the HLA-A and -B loci mainly on lymphoblasts and missed specificities mainly at the HLA-B locus on myeloblasts. Lack of A,B antigens was complete in 6.2% of all tested samples (9% of ANLL) and selective for all the products of one locus in 16.8% of all tested samples (27.7% of ANLL). A decrease of class I molecules on the cell surface was evidenced with MoAb W6/32 on blasts missing detectable serological specificities.

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SN - 0305-1811

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JO - Journal of Immunogenetics

JF - Journal of Immunogenetics

IS - 3

ER -

Altered expression of HLA-A,B specificities on acute lymphoid and myeloid leukaemia blasts

Abstract

ASJC Scopus subject areas

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