Alpha-1-antitrypsin phenotypes in malignant lymphoma

Francesco Callea, Guido Massi, Chris De Wolf-Peeters, Carl Lievens, Valeer J. Desmet

Research output: Contribution to journalArticlepeer-review


The alpha-1-antitrypsin (α1, AT) Pi phenotypes have been determined by isoelectric focusing in a series of 228 patients having a histologically diagnosed malignant lymphoma and in 250 healthy controls. The Pi MZ phenotype occurred in 13 patients with lymphoma (5.8%) and in five of 250 healthy individuals (2%). Furthermore, one patient with a Pi SS and three patients with an abnormal unknown phenotype, migrating slower than Z, were found in the lymphoma group. No prevalence for a special lymphoma type was observed among the abnormal Pi phenotype patients. The increased incidence of abnormal Pi phenotypes in malignant lymphoma's support the hypothesis of the possible role of α1, AT in development of immunopathological disorders.

Original languageEnglish
Pages (from-to)1213-1215
Number of pages3
JournalJournal of Clinical Pathology
Issue number11
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Health Policy
  • Pathology and Forensic Medicine


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