TY - JOUR
T1 - Allogeneic peripheral blood stem cell transplantation with reduced intensity conditioning in primary refractory prolymphocytic leukemia
T2 - Graft-versus-leukemia effect without graft-versus-host disease
AU - Castagna, L.
AU - Nozza, A.
AU - Bertuzzi, A.
AU - Siracusano, L.
AU - Timofeeva, I.
AU - Santoro, A.
PY - 2001
Y1 - 2001
N2 - A patient with progressive prolymphocytic leukemia (PLL) received an allogeneic stem cell transplant using a reduced intensity conditioning regimen to avoid prohibitive toxicities. Early in the post-transplant period, a high donor-derived CD8+ count was observed. One year from transplantation, the patient was in complete remission, fully donor chimeric and with a normal performance status, suggesting that this approach may represent a useful treatment option in patients with refractory PLL.
AB - A patient with progressive prolymphocytic leukemia (PLL) received an allogeneic stem cell transplant using a reduced intensity conditioning regimen to avoid prohibitive toxicities. Early in the post-transplant period, a high donor-derived CD8+ count was observed. One year from transplantation, the patient was in complete remission, fully donor chimeric and with a normal performance status, suggesting that this approach may represent a useful treatment option in patients with refractory PLL.
KW - Allogeneic stem cell transplantation
KW - Nonmyeloablative conditioning regimen
KW - Prolymphocytic leukemia
UR - http://www.scopus.com/inward/record.url?scp=0035691713&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035691713&partnerID=8YFLogxK
U2 - 10.1038/sj.bmt.1703309
DO - 10.1038/sj.bmt.1703309
M3 - Article
C2 - 11803359
AN - SCOPUS:0035691713
SN - 0268-3369
VL - 28
SP - 1155
EP - 1156
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 12
ER -