Allergy to betalactams and nucleotide-binding oligomerization domain (NOD) gene polymorphisms

A. C. Bursztejn; A. Romano; R. M. Guéant-Rodriguez; J. A. Cornejo; A. Oussalah; C. Chery; I. Gastin; F. Gaeta; A. Barbaud; M. Blanca; J. L. Guéant

doi:10.1111/all.12196

Allergy to betalactams and nucleotide-binding oligomerization domain (NOD) gene polymorphisms

A. C. Bursztejn, A. Romano, R. M. Guéant-Rodriguez, J. A. Cornejo, A. Oussalah, C. Chery, I. Gastin, F. Gaeta, A. Barbaud, M. Blanca, J. L. Guéant

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Abstract

Background Polymorphisms of interleukin genes related to IgE production and inflammation are predictors of hypersensitivity to betalactam, but nothing is known on the influence of NOD genes, despite their association with inflammation and atopy. Objective To evaluate the association of NOD2 and NOD1 polymorphisms with betalactam allergy. Method We genotyped 3 polymorphisms of NOD2 and 1 of NOD1 in 368 Italian and 387 Spanish patients, compared with 368 and 326 controls, respectively. Results CT/TT genotypes of rs2066845 of NOD2 predicted a lower risk in Italy (P = 0.003), while WT/insC genotype of rs5743293 (also in leucine-rich repeat domain) predicted a higher risk in Spain (P = 0.007). G allele of rs2066845 was associated with a higher level of IgE in the Italian population. Conclusion The mirrored influence of these NOD2 polymorphisms on betalactam allergy in two populations suggests a link with pathways of inflammation and/or atopy through mechanisms, which need to be clarified.

Original language	English
Pages (from-to)	1076-1080
Number of pages	5
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	68
Issue number	8
DOIs	https://doi.org/10.1111/all.12196
Publication status	Published - Aug 2013

Keywords

betalactam allergy
IgE
NOD gene
polymorphism

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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10.1111/all.12196

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Bursztejn, A. C., Romano, A., Guéant-Rodriguez, R. M., Cornejo, J. A., Oussalah, A., Chery, C., Gastin, I., Gaeta, F., Barbaud, A., Blanca, M., & Guéant, J. L. (2013). Allergy to betalactams and nucleotide-binding oligomerization domain (NOD) gene polymorphisms. Allergy: European Journal of Allergy and Clinical Immunology, 68(8), 1076-1080. https://doi.org/10.1111/all.12196

Bursztejn, AC, Romano, A, Guéant-Rodriguez, RM, Cornejo, JA, Oussalah, A, Chery, C, Gastin, I, Gaeta, F, Barbaud, A, Blanca, M & Guéant, JL 2013, 'Allergy to betalactams and nucleotide-binding oligomerization domain (NOD) gene polymorphisms', Allergy: European Journal of Allergy and Clinical Immunology, vol. 68, no. 8, pp. 1076-1080. https://doi.org/10.1111/all.12196

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abstract = "Background Polymorphisms of interleukin genes related to IgE production and inflammation are predictors of hypersensitivity to betalactam, but nothing is known on the influence of NOD genes, despite their association with inflammation and atopy. Objective To evaluate the association of NOD2 and NOD1 polymorphisms with betalactam allergy. Method We genotyped 3 polymorphisms of NOD2 and 1 of NOD1 in 368 Italian and 387 Spanish patients, compared with 368 and 326 controls, respectively. Results CT/TT genotypes of rs2066845 of NOD2 predicted a lower risk in Italy (P = 0.003), while WT/insC genotype of rs5743293 (also in leucine-rich repeat domain) predicted a higher risk in Spain (P = 0.007). G allele of rs2066845 was associated with a higher level of IgE in the Italian population. Conclusion The mirrored influence of these NOD2 polymorphisms on betalactam allergy in two populations suggests a link with pathways of inflammation and/or atopy through mechanisms, which need to be clarified.",

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author = "Bursztejn, {A. C.} and A. Romano and Gu{\'e}ant-Rodriguez, {R. M.} and Cornejo, {J. A.} and A. Oussalah and C. Chery and I. Gastin and F. Gaeta and A. Barbaud and M. Blanca and Gu{\'e}ant, {J. L.}",

year = "2013",

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doi = "10.1111/all.12196",

language = "English",

volume = "68",

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AU - Romano, A.

AU - Guéant-Rodriguez, R. M.

AU - Cornejo, J. A.

AU - Oussalah, A.

AU - Chery, C.

AU - Gastin, I.

AU - Gaeta, F.

AU - Barbaud, A.

AU - Blanca, M.

AU - Guéant, J. L.

PY - 2013/8

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N2 - Background Polymorphisms of interleukin genes related to IgE production and inflammation are predictors of hypersensitivity to betalactam, but nothing is known on the influence of NOD genes, despite their association with inflammation and atopy. Objective To evaluate the association of NOD2 and NOD1 polymorphisms with betalactam allergy. Method We genotyped 3 polymorphisms of NOD2 and 1 of NOD1 in 368 Italian and 387 Spanish patients, compared with 368 and 326 controls, respectively. Results CT/TT genotypes of rs2066845 of NOD2 predicted a lower risk in Italy (P = 0.003), while WT/insC genotype of rs5743293 (also in leucine-rich repeat domain) predicted a higher risk in Spain (P = 0.007). G allele of rs2066845 was associated with a higher level of IgE in the Italian population. Conclusion The mirrored influence of these NOD2 polymorphisms on betalactam allergy in two populations suggests a link with pathways of inflammation and/or atopy through mechanisms, which need to be clarified.

AB - Background Polymorphisms of interleukin genes related to IgE production and inflammation are predictors of hypersensitivity to betalactam, but nothing is known on the influence of NOD genes, despite their association with inflammation and atopy. Objective To evaluate the association of NOD2 and NOD1 polymorphisms with betalactam allergy. Method We genotyped 3 polymorphisms of NOD2 and 1 of NOD1 in 368 Italian and 387 Spanish patients, compared with 368 and 326 controls, respectively. Results CT/TT genotypes of rs2066845 of NOD2 predicted a lower risk in Italy (P = 0.003), while WT/insC genotype of rs5743293 (also in leucine-rich repeat domain) predicted a higher risk in Spain (P = 0.007). G allele of rs2066845 was associated with a higher level of IgE in the Italian population. Conclusion The mirrored influence of these NOD2 polymorphisms on betalactam allergy in two populations suggests a link with pathways of inflammation and/or atopy through mechanisms, which need to be clarified.

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Allergy to betalactams and nucleotide-binding oligomerization domain (NOD) gene polymorphisms

Abstract

Keywords

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