TY - JOUR
T1 - Aldosterone synthase alleles and cardiovascular phenotype in young adults
AU - Sarzani, R.
AU - Salvi, F.
AU - Dessí-Fulgheri, P.
AU - Catalini, R.
AU - Mazzara, D.
AU - Cola, G.
AU - Siragusa, N.
AU - Spagnolo, D.
AU - Ercolani, P.
AU - Gesuita, R.
AU - Carle, F.
AU - Rappelli, A.
PY - 2003/12
Y1 - 2003/12
N2 - The C(-344)T promoter polymorphism of the human aldosterone synthase (CYP11B2) gene has been associated with hypertension and cardiac hypertrophy, but there were contrasting data. We analysed the genotype/phenotype associations between this polymorphism and cardiovascular variables in a young adult population, where interactions among genes, gene-environment, and acquired ageing-related organ damage are reduced. Anthropometric measurements, blood pressure, heart rate, left ventricular variables (by echocardiography), and carotid artery wall intimal-media thickness (by high-resolution sonography and digitalized morphometry) were taken in 420 white Caucasian students (mean age 23.5 years, s.d. 2.5 years). CYP11B2 alleles were detected by genomic polymerase chain reaction followed by digestion. Taking into account the three possible models of inheritance, we found no differences in the considered variables, except for an independent effect of the C(-344) allele on SBP in males (TT 125.6 (1.6), TC 128.4 (1.2) and CC 130.5 (2.2), mmHg, media (ES), P=0.03), and on interventricular septum thickness in diastole in females (CC 6.98 (0.12) vs TT 6.87 (0.09) and TC 6.87 (0.07), mmHg, P
AB - The C(-344)T promoter polymorphism of the human aldosterone synthase (CYP11B2) gene has been associated with hypertension and cardiac hypertrophy, but there were contrasting data. We analysed the genotype/phenotype associations between this polymorphism and cardiovascular variables in a young adult population, where interactions among genes, gene-environment, and acquired ageing-related organ damage are reduced. Anthropometric measurements, blood pressure, heart rate, left ventricular variables (by echocardiography), and carotid artery wall intimal-media thickness (by high-resolution sonography and digitalized morphometry) were taken in 420 white Caucasian students (mean age 23.5 years, s.d. 2.5 years). CYP11B2 alleles were detected by genomic polymerase chain reaction followed by digestion. Taking into account the three possible models of inheritance, we found no differences in the considered variables, except for an independent effect of the C(-344) allele on SBP in males (TT 125.6 (1.6), TC 128.4 (1.2) and CC 130.5 (2.2), mmHg, media (ES), P=0.03), and on interventricular septum thickness in diastole in females (CC 6.98 (0.12) vs TT 6.87 (0.09) and TC 6.87 (0.07), mmHg, P
KW - Aldosterone synthase
KW - Alleles
KW - Blood pressure
KW - Cardiac hypertrophy
KW - Young
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U2 - 10.1038/sj.jhh.1001619
DO - 10.1038/sj.jhh.1001619
M3 - Article
C2 - 14704730
AN - SCOPUS:9144272668
SN - 0950-9240
VL - 17
SP - 859
EP - 864
JO - Journal of Human Hypertension
JF - Journal of Human Hypertension
IS - 12
ER -