Aldose reductase inhibitors: pharmacological data and therapeutic perspectives

N. Canal, G. Comi

Research output: Contribution to journalArticlepeer-review


The activation of the 'polyol pathway' in diabetes, inducing an accumulation of sorbitol in peripheral nerve, is an important factor in the pathogenesis of diabetic polyneuritis. Inhibitors of aldose reductase - antagonizing sorbitol accumulation - restore the conduction velocity of nerves both in experimental and in human diabetes. Nicholas Canal and Giancarlo Comi evaluate their potential therapeutic effectiveness.

Original languageEnglish
Pages (from-to)328-330
Number of pages3
JournalTrends in Pharmacological Sciences
Issue numberC
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology


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