TY - JOUR
T1 - Aldose reductase inhibitors
T2 - pharmacological data and therapeutic perspectives
AU - Canal, N.
AU - Comi, G.
PY - 1985
Y1 - 1985
N2 - The activation of the 'polyol pathway' in diabetes, inducing an accumulation of sorbitol in peripheral nerve, is an important factor in the pathogenesis of diabetic polyneuritis. Inhibitors of aldose reductase - antagonizing sorbitol accumulation - restore the conduction velocity of nerves both in experimental and in human diabetes. Nicholas Canal and Giancarlo Comi evaluate their potential therapeutic effectiveness.
AB - The activation of the 'polyol pathway' in diabetes, inducing an accumulation of sorbitol in peripheral nerve, is an important factor in the pathogenesis of diabetic polyneuritis. Inhibitors of aldose reductase - antagonizing sorbitol accumulation - restore the conduction velocity of nerves both in experimental and in human diabetes. Nicholas Canal and Giancarlo Comi evaluate their potential therapeutic effectiveness.
UR - http://www.scopus.com/inward/record.url?scp=0343541278&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0343541278&partnerID=8YFLogxK
U2 - 10.1016/0165-6147(85)90152-X
DO - 10.1016/0165-6147(85)90152-X
M3 - Article
AN - SCOPUS:0343541278
SN - 0165-6147
VL - 6
SP - 328
EP - 330
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - C
ER -