TY - JOUR
T1 - Agreement between multi-dimensional and renal-specific response criteria in patients with juvenile systemic lupus erythematosus and renal disease
AU - Ruperto, Nicolino
AU - Bazso, A.
AU - Pistorio, A.
AU - Ravelli, A.
AU - Filocamo, G.
AU - Hernandez Huirache, H. G.
AU - Rodriguez Lozano, A. L.
AU - Pringe, A. B.
AU - Vilca, I.
AU - Martini, A.
PY - 2010
Y1 - 2010
N2 - Objective: To evaluate change over time and level of agreement of renal-specific and multi-dimensional measures in juvenile systemic lupus erythematosus (SLE) with renal disease. Methods: An analysis was made of 205/557 children with baseline 24-hour proteinuria 2:05 g. Data were collected at baseline, 6-, 12- and 24-month intervals. Using the Systemic Lupus International Collaborating Clinics (SLICC) renal index (change in proteinuria and urine sediment) as gold standard, responsiveness and discriminative ability analyses were used to identify key renal and multi-dimensional disease activity and damage measures for the evaluation of response to therapy. We also evaluated the kappa agreement between SLICC renal index and PRINTO/ACR juvenile SLE criteria (change in proteinuria, physician and parents evaluations, disease activity, health related quality of life [HRQOL]). Results: Children with renal disease compared to children without renal disease, had a lower female rate and higher disease activity/response rate (p-values
AB - Objective: To evaluate change over time and level of agreement of renal-specific and multi-dimensional measures in juvenile systemic lupus erythematosus (SLE) with renal disease. Methods: An analysis was made of 205/557 children with baseline 24-hour proteinuria 2:05 g. Data were collected at baseline, 6-, 12- and 24-month intervals. Using the Systemic Lupus International Collaborating Clinics (SLICC) renal index (change in proteinuria and urine sediment) as gold standard, responsiveness and discriminative ability analyses were used to identify key renal and multi-dimensional disease activity and damage measures for the evaluation of response to therapy. We also evaluated the kappa agreement between SLICC renal index and PRINTO/ACR juvenile SLE criteria (change in proteinuria, physician and parents evaluations, disease activity, health related quality of life [HRQOL]). Results: Children with renal disease compared to children without renal disease, had a lower female rate and higher disease activity/response rate (p-values
KW - Core set
KW - Disease activity
KW - Juvenile systemic lupus erythematosus
KW - Response to therapy
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M3 - Article
C2 - 20497629
AN - SCOPUS:77957002526
SN - 0392-856X
VL - 28
SP - 424
EP - 433
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
IS - 3
ER -