Age-related changes in the function and structure of the peripheral sensory pathway in mice

Annalisa Canta, Alessia Chiorazzi, Valentina Alda Carozzi, Cristina Meregalli, Norberto Oggioni, Mario Bossi, Virginia Rodriguez-Menendez, Federica Avezza, Luca Crippa, Raffaella Lombardi, Giuseppe de Vito, Vincenzo Piazza, Guido Cavaletti, Paola Marmiroli

Research output: Contribution to journalArticlepeer-review


This study is aimed at describing the changes occurring in the entire peripheral nervous system sensory pathway along a 2-year observation period in a cohort of C57BL/6 mice. The neurophysiological studies evidenced significant differences in the selected time points corresponding to childhood, young adulthood, adulthood, and aging (i.e., 1, 7, 15, and 25 months of age), with a parabolic course as function of time. The pathological assessment allowed to demonstrate signs of age-related changes since the age of 7 months, with a remarkable increase in both peripheral nerves and dorsal root ganglia at the subsequent time points. These changes were mainly in the myelin sheaths, as also confirmed by the Rotating-Polarization Coherent-Anti-stokes-Raman-scattering microscopy analysis. Evident changes were also present at the morphometric analysis performed on the peripheral nerves, dorsal root ganglia neurons, and skin biopsies. This extensive, multimodal characterization of the peripheral nervous system changes in aging provides the background for future mechanistic studies allowing the selection of the most appropriate time points and readouts according to the investigation aims.

Original languageEnglish
Pages (from-to)136-148
Number of pages13
JournalNeurobiology of Aging
Publication statusPublished - Sept 1 2016


  • Aging
  • Mice
  • Morphometric analysis
  • Nerve conduction velocity
  • Peripheral nervous system

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology


Dive into the research topics of 'Age-related changes in the function and structure of the peripheral sensory pathway in mice'. Together they form a unique fingerprint.

Cite this