TY - JOUR
T1 - Age of onset of myocardial infarction
T2 - Is promoter polymorphism of the RAGE gene implicated?
AU - Boiocchi, Chiara
AU - Bozzini, Sara
AU - Buzzi, Maria Paola
AU - Schirinzi, Sandra
AU - Zorzetto, Michele
AU - Pelissero, Gabriele
AU - Cuccia, Mariaclara
AU - Falcone, Colomba
PY - 2011/2/1
Y1 - 2011/2/1
N2 - Receptor for advanced glycation endproducts (RAGE) is a cell-surface molecule member of the immunoglobulin superfamily and engages differing ligands relevant to distinct processes. A growing body of evidence has suggested that RAGE may promote vascular inflammation through several mechanisms. The objective of this study was to identify the possible relationship between the -374 T/A polymorphism of the RAGE gene, myocardial infarction (MI), and its age of onset. A total of 691 MI patients and 234 matched controls were investigated. In this study, the frequency of the A allele and AA genotype of the -374 T/A promoter polymorphism is significantly lower in patients with MI respect to the control group (p
AB - Receptor for advanced glycation endproducts (RAGE) is a cell-surface molecule member of the immunoglobulin superfamily and engages differing ligands relevant to distinct processes. A growing body of evidence has suggested that RAGE may promote vascular inflammation through several mechanisms. The objective of this study was to identify the possible relationship between the -374 T/A polymorphism of the RAGE gene, myocardial infarction (MI), and its age of onset. A total of 691 MI patients and 234 matched controls were investigated. In this study, the frequency of the A allele and AA genotype of the -374 T/A promoter polymorphism is significantly lower in patients with MI respect to the control group (p
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U2 - 10.1089/rej.2010.1091
DO - 10.1089/rej.2010.1091
M3 - Article
C2 - 21208063
AN - SCOPUS:79951825591
SN - 1549-1684
VL - 14
SP - 67
EP - 73
JO - Rejuvenation Research
JF - Rejuvenation Research
IS - 1
ER -