Age of onset in vitiligo: Relationship with HLA supratypes

O. Finco; M. Cuccia; M. Martinetti; G. Ruberto; G. Orecchia; G. Rabbiosi

Age of onset in vitiligo: Relationship with HLA supratypes

O. Finco, M. Cuccia, M. Martinetti, G. Ruberto, G. Orecchia, G. Rabbiosi

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

HLA class I (A, B, C), class II (DR, DQ) histoglobulins and HLA class III (C4A, C4B and Bf) complement factors were analysed in 87 patients with vitiligo and in controls. Two HLA supratypes seem to mark different age of onset of vitiligo: HLA-BfS, C4A3, C4B1, DR5 (W11), DQW3 is characteristic of the pediatric form; while HLA-Bfs, C4A3, C4B1, DR7, DQW2 marks the adult form of disease. The importance of defining HLA supratype, not single alleles, is discussed.

Original language	English
Pages (from-to)	48-54
Number of pages	7
Journal	Clinical Genetics
Volume	39
Issue number	1
Publication status	Published - 1991

Keywords

C4 and Bf complement factors
genetic heterogenicity
HLA
vitiligo

ASJC Scopus subject areas

Genetics(clinical)
Genetics

Cite this

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abstract = "HLA class I (A, B, C), class II (DR, DQ) histoglobulins and HLA class III (C4A, C4B and Bf) complement factors were analysed in 87 patients with vitiligo and in controls. Two HLA supratypes seem to mark different age of onset of vitiligo: HLA-BfS, C4A3, C4B1, DR5 (W11), DQW3 is characteristic of the pediatric form; while HLA-Bfs, C4A3, C4B1, DR7, DQW2 marks the adult form of disease. The importance of defining HLA supratype, not single alleles, is discussed.",

keywords = "C4 and Bf complement factors, genetic heterogenicity, HLA, vitiligo",

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T2 - Relationship with HLA supratypes

AU - Finco, O.

AU - Cuccia, M.

AU - Martinetti, M.

AU - Ruberto, G.

AU - Orecchia, G.

AU - Rabbiosi, G.

PY - 1991

Y1 - 1991

N2 - HLA class I (A, B, C), class II (DR, DQ) histoglobulins and HLA class III (C4A, C4B and Bf) complement factors were analysed in 87 patients with vitiligo and in controls. Two HLA supratypes seem to mark different age of onset of vitiligo: HLA-BfS, C4A3, C4B1, DR5 (W11), DQW3 is characteristic of the pediatric form; while HLA-Bfs, C4A3, C4B1, DR7, DQW2 marks the adult form of disease. The importance of defining HLA supratype, not single alleles, is discussed.

AB - HLA class I (A, B, C), class II (DR, DQ) histoglobulins and HLA class III (C4A, C4B and Bf) complement factors were analysed in 87 patients with vitiligo and in controls. Two HLA supratypes seem to mark different age of onset of vitiligo: HLA-BfS, C4A3, C4B1, DR5 (W11), DQW3 is characteristic of the pediatric form; while HLA-Bfs, C4A3, C4B1, DR7, DQW2 marks the adult form of disease. The importance of defining HLA supratype, not single alleles, is discussed.

KW - C4 and Bf complement factors

KW - genetic heterogenicity

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Age of onset in vitiligo: Relationship with HLA supratypes

Abstract

Keywords

ASJC Scopus subject areas

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