Age-dependent effect of susceptibility factors on the risk of intracerebral haemorrhage: Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy)

Martina Locatelli; Mario Grassi; Valentina Saba; Licia Iacovello; Augusto di Castelnuovo; Giovanni de Gaetano; Marialuisa Zedde; Simona Marcheselli; Giorgio Silvestrelli; Alfonso Ciccone; Maria Luisa Delodovici; Lucia Princiotta Cariddi; Alessia Giossi; Andrea Zini; Maurizio Paciaroni; Monica Acciarresi; Cristiano Azzini; Alessandro De Vito; Massimo Gamba; Mauro Magoni; Massimo Del Sette; Antonella Toriello; Carlo Gandolfo; Cinzia Finocchi; Domenico Marco Bonifati; Rossana Tassi; Giuseppe Martini; Anna Cavallini; Andrea Morotti; Sonia Bonacina; Valentina Mazzoleni; Debora Pezzini; Alberto Chiti; Rocco Salvatore Calabrò; Rosa Musolino; Paolo La Spina; Francesco Grillo; Giampaolo Tomelleri; Corrado Lodigiani; Marco Ritelli; Marina Colombi; Alessandro Padovani; Alessandro Pezzini

doi:10.1136/jnnp-2020-325648

Age-dependent effect of susceptibility factors on the risk of intracerebral haemorrhage: Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy)

Martina Locatelli, Mario Grassi, Valentina Saba, Licia Iacovello, Augusto di Castelnuovo, Giovanni de Gaetano, Marialuisa Zedde, Simona Marcheselli, Giorgio Silvestrelli, Alfonso Ciccone, Maria Luisa Delodovici, Lucia Princiotta Cariddi, Alessia Giossi, Andrea Zini, Maurizio Paciaroni, Monica Acciarresi, Cristiano Azzini, Alessandro De Vito, Massimo Gamba, Mauro MagoniMassimo Del Sette, Antonella Toriello, Carlo Gandolfo, Cinzia Finocchi, Domenico Marco Bonifati, Rossana Tassi, Giuseppe Martini, Anna Cavallini, Andrea Morotti, Sonia Bonacina, Valentina Mazzoleni, Debora Pezzini, Alberto Chiti, Rocco Salvatore Calabrò, Rosa Musolino, Paolo La Spina, Francesco Grillo, Giampaolo Tomelleri, Corrado Lodigiani, Marco Ritelli, Marina Colombi, Alessandro Padovani, Alessandro Pezzini

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To investigate the age-dependent impact of traditional stroke risk factors on the occurrence of intracerebral haemorrhage (ICH).

METHODS: We performed a case-control analysis, comparing consecutive patients with ICH with age-matched and sex-matched stroke-free controls, enrolled in the setting of the Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy) between 2002 and 2014 by multivariable logistic regression model within subgroups stratified by age quartiles (Q1-Q4).

RESULTS: We analysed 3492 patients and 3492 controls. The impact of untreated hypertension on the risk of ICH was higher in the lower than in the upper age quartile (OR 11.64, 95% CI 7.68 to 17.63 in Q1 vs OR 6.05, 95% CI 3.09 to 11.85 in Q4 with intermediate ORs in Q2 and Q3), while the opposite trend was observed for untreated hypercholesterolaemia (OR 0.63, 95% CI 0.45 to 0.97 in Q1 vs OR 0.36, 95% CI 0.26 to 0.56 in Q4 with intermediate ORs in Q2 and Q3). The effect of untreated diabetes and excessive alcohol intake was detected only in the older age group (OR 3.63, 95% CI 1.22 to 10.73, and OR 1.69, 95% CI 1.13 to 2.51, respectively).

CONCLUSIONS: Our findings provide evidence of age-dependent differences in the effects of susceptibility factors on the risk of ICH.

Original language	English
Journal	Journal of neurology, neurosurgery, and psychiatry
DOIs	https://doi.org/10.1136/jnnp-2020-325648
Publication status	E-pub ahead of print - Jul 12 2021

Access to Document

10.1136/jnnp-2020-325648

Cite this

Locatelli, M., Grassi, M., Saba, V., Iacovello, L., di Castelnuovo, A., de Gaetano, G., Zedde, M., Marcheselli, S., Silvestrelli, G., Ciccone, A., Delodovici, M. L., Princiotta Cariddi, L., Giossi, A., Zini, A., Paciaroni, M., Acciarresi, M., Azzini, C., De Vito, A., Gamba, M., ... Pezzini, A. (2021). Age-dependent effect of susceptibility factors on the risk of intracerebral haemorrhage: Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy). Journal of neurology, neurosurgery, and psychiatry. https://doi.org/10.1136/jnnp-2020-325648

Locatelli, M, Grassi, M, Saba, V, Iacovello, L, di Castelnuovo, A, de Gaetano, G, Zedde, M, Marcheselli, S, Silvestrelli, G, Ciccone, A, Delodovici, ML, Princiotta Cariddi, L, Giossi, A, Zini, A, Paciaroni, M, Acciarresi, M, Azzini, C, De Vito, A, Gamba, M, Magoni, M, Del Sette, M, Toriello, A, Gandolfo, C, Finocchi, C, Bonifati, DM, Tassi, R, Martini, G, Cavallini, A, Morotti, A, Bonacina, S, Mazzoleni, V, Pezzini, D, Chiti, A, Calabrò, RS, Musolino, R, La Spina, P, Grillo, F, Tomelleri, G, Lodigiani, C, Ritelli, M, Colombi, M, Padovani, A & Pezzini, A 2021, 'Age-dependent effect of susceptibility factors on the risk of intracerebral haemorrhage: Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy)', Journal of neurology, neurosurgery, and psychiatry. https://doi.org/10.1136/jnnp-2020-325648

@article{46f78b4f5f18493fb7b2e077c09b48d6,

title = "Age-dependent effect of susceptibility factors on the risk of intracerebral haemorrhage: Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy)",

abstract = "OBJECTIVE: To investigate the age-dependent impact of traditional stroke risk factors on the occurrence of intracerebral haemorrhage (ICH).METHODS: We performed a case-control analysis, comparing consecutive patients with ICH with age-matched and sex-matched stroke-free controls, enrolled in the setting of the Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy) between 2002 and 2014 by multivariable logistic regression model within subgroups stratified by age quartiles (Q1-Q4).RESULTS: We analysed 3492 patients and 3492 controls. The impact of untreated hypertension on the risk of ICH was higher in the lower than in the upper age quartile (OR 11.64, 95% CI 7.68 to 17.63 in Q1 vs OR 6.05, 95% CI 3.09 to 11.85 in Q4 with intermediate ORs in Q2 and Q3), while the opposite trend was observed for untreated hypercholesterolaemia (OR 0.63, 95% CI 0.45 to 0.97 in Q1 vs OR 0.36, 95% CI 0.26 to 0.56 in Q4 with intermediate ORs in Q2 and Q3). The effect of untreated diabetes and excessive alcohol intake was detected only in the older age group (OR 3.63, 95% CI 1.22 to 10.73, and OR 1.69, 95% CI 1.13 to 2.51, respectively).CONCLUSIONS: Our findings provide evidence of age-dependent differences in the effects of susceptibility factors on the risk of ICH.",

author = "Martina Locatelli and Mario Grassi and Valentina Saba and Licia Iacovello and {di Castelnuovo}, Augusto and {de Gaetano}, Giovanni and Marialuisa Zedde and Simona Marcheselli and Giorgio Silvestrelli and Alfonso Ciccone and Delodovici, {Maria Luisa} and {Princiotta Cariddi}, Lucia and Alessia Giossi and Andrea Zini and Maurizio Paciaroni and Monica Acciarresi and Cristiano Azzini and {De Vito}, Alessandro and Massimo Gamba and Mauro Magoni and {Del Sette}, Massimo and Antonella Toriello and Carlo Gandolfo and Cinzia Finocchi and Bonifati, {Domenico Marco} and Rossana Tassi and Giuseppe Martini and Anna Cavallini and Andrea Morotti and Sonia Bonacina and Valentina Mazzoleni and Debora Pezzini and Alberto Chiti and Calabr{\`o}, {Rocco Salvatore} and Rosa Musolino and {La Spina}, Paolo and Francesco Grillo and Giampaolo Tomelleri and Corrado Lodigiani and Marco Ritelli and Marina Colombi and Alessandro Padovani and Alessandro Pezzini",

note = "{\textcopyright} Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.",

year = "2021",

month = jul,

day = "12",

doi = "10.1136/jnnp-2020-325648",

language = "English",

journal = "Journal of Neurology, Neurosurgery and Psychiatry",

issn = "0022-3050",

publisher = "BMJ Publishing Group",

}

TY - JOUR

T1 - Age-dependent effect of susceptibility factors on the risk of intracerebral haemorrhage

T2 - Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy)

AU - Locatelli, Martina

AU - Grassi, Mario

AU - Saba, Valentina

AU - Iacovello, Licia

AU - di Castelnuovo, Augusto

AU - de Gaetano, Giovanni

AU - Zedde, Marialuisa

AU - Marcheselli, Simona

AU - Silvestrelli, Giorgio

AU - Ciccone, Alfonso

AU - Delodovici, Maria Luisa

AU - Princiotta Cariddi, Lucia

AU - Giossi, Alessia

AU - Zini, Andrea

AU - Paciaroni, Maurizio

AU - Acciarresi, Monica

AU - Azzini, Cristiano

AU - De Vito, Alessandro

AU - Gamba, Massimo

AU - Magoni, Mauro

AU - Del Sette, Massimo

AU - Toriello, Antonella

AU - Gandolfo, Carlo

AU - Finocchi, Cinzia

AU - Bonifati, Domenico Marco

AU - Tassi, Rossana

AU - Martini, Giuseppe

AU - Cavallini, Anna

AU - Morotti, Andrea

AU - Bonacina, Sonia

AU - Mazzoleni, Valentina

AU - Pezzini, Debora

AU - Chiti, Alberto

AU - Calabrò, Rocco Salvatore

AU - Musolino, Rosa

AU - La Spina, Paolo

AU - Grillo, Francesco

AU - Tomelleri, Giampaolo

AU - Lodigiani, Corrado

AU - Ritelli, Marco

AU - Colombi, Marina

AU - Padovani, Alessandro

AU - Pezzini, Alessandro

PY - 2021/7/12

Y1 - 2021/7/12

N2 - OBJECTIVE: To investigate the age-dependent impact of traditional stroke risk factors on the occurrence of intracerebral haemorrhage (ICH).METHODS: We performed a case-control analysis, comparing consecutive patients with ICH with age-matched and sex-matched stroke-free controls, enrolled in the setting of the Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy) between 2002 and 2014 by multivariable logistic regression model within subgroups stratified by age quartiles (Q1-Q4).RESULTS: We analysed 3492 patients and 3492 controls. The impact of untreated hypertension on the risk of ICH was higher in the lower than in the upper age quartile (OR 11.64, 95% CI 7.68 to 17.63 in Q1 vs OR 6.05, 95% CI 3.09 to 11.85 in Q4 with intermediate ORs in Q2 and Q3), while the opposite trend was observed for untreated hypercholesterolaemia (OR 0.63, 95% CI 0.45 to 0.97 in Q1 vs OR 0.36, 95% CI 0.26 to 0.56 in Q4 with intermediate ORs in Q2 and Q3). The effect of untreated diabetes and excessive alcohol intake was detected only in the older age group (OR 3.63, 95% CI 1.22 to 10.73, and OR 1.69, 95% CI 1.13 to 2.51, respectively).CONCLUSIONS: Our findings provide evidence of age-dependent differences in the effects of susceptibility factors on the risk of ICH.

AB - OBJECTIVE: To investigate the age-dependent impact of traditional stroke risk factors on the occurrence of intracerebral haemorrhage (ICH).METHODS: We performed a case-control analysis, comparing consecutive patients with ICH with age-matched and sex-matched stroke-free controls, enrolled in the setting of the Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy) between 2002 and 2014 by multivariable logistic regression model within subgroups stratified by age quartiles (Q1-Q4).RESULTS: We analysed 3492 patients and 3492 controls. The impact of untreated hypertension on the risk of ICH was higher in the lower than in the upper age quartile (OR 11.64, 95% CI 7.68 to 17.63 in Q1 vs OR 6.05, 95% CI 3.09 to 11.85 in Q4 with intermediate ORs in Q2 and Q3), while the opposite trend was observed for untreated hypercholesterolaemia (OR 0.63, 95% CI 0.45 to 0.97 in Q1 vs OR 0.36, 95% CI 0.26 to 0.56 in Q4 with intermediate ORs in Q2 and Q3). The effect of untreated diabetes and excessive alcohol intake was detected only in the older age group (OR 3.63, 95% CI 1.22 to 10.73, and OR 1.69, 95% CI 1.13 to 2.51, respectively).CONCLUSIONS: Our findings provide evidence of age-dependent differences in the effects of susceptibility factors on the risk of ICH.

U2 - 10.1136/jnnp-2020-325648

DO - 10.1136/jnnp-2020-325648

M3 - Article

C2 - 34253639

SN - 0022-3050

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

ER -

Age-dependent effect of susceptibility factors on the risk of intracerebral haemorrhage: Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy)

Abstract

Access to Document

Fingerprint

Cite this