Aerobic training and angiogenesis activation in patients with stable chronic heart failure: A preliminary report

Ermanno Eleuteri; Alessandro Mezzani; Antonino Di Stefano; Davide Vallese; Isabella Gnemmi; Lorena Delle Donne; Adriano Taddeo; Silvia Della Bella; Pantaleo Giannuzzi

doi:10.3109/1354750X.2013.805342

Aerobic training and angiogenesis activation in patients with stable chronic heart failure: A preliminary report

Ermanno Eleuteri, Alessandro Mezzani, Antonino Di Stefano, Davide Vallese, Isabella Gnemmi, Lorena Delle Donne, Adriano Taddeo, Silvia Della Bella, Pantaleo Giannuzzi

Research output: Contribution to journal › Article › peer-review

Abstract

The pathophysiology of chronic heart failure (CHF) involves multiple hystologic and molecular alterations. To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1α) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64+2 years, NYHA 2). At the end of the study, EPCs count and AP-2 serum levels significantly increased in the CHF-TR group. These preliminary data suggest a significant effect of even a short program of physical training on angiogenic activation and endothelial dysfunction.

Original language	English
Pages (from-to)	418-424
Number of pages	7
Journal	Biomarkers
Volume	18
Issue number	5
DOIs	https://doi.org/10.3109/1354750X.2013.805342
Publication status	Published - Aug 2013

Keywords

Cardiovascular disease
Growth factors/cytokines/inflammatory mediators
Sports science/exercise

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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10.3109/1354750X.2013.805342

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title = "Aerobic training and angiogenesis activation in patients with stable chronic heart failure: A preliminary report",

abstract = "The pathophysiology of chronic heart failure (CHF) involves multiple hystologic and molecular alterations. To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1α) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64+2 years, NYHA 2). At the end of the study, EPCs count and AP-2 serum levels significantly increased in the CHF-TR group. These preliminary data suggest a significant effect of even a short program of physical training on angiogenic activation and endothelial dysfunction.",

keywords = "Cardiovascular disease, Growth factors/cytokines/inflammatory mediators, Sports science/exercise",

author = "Ermanno Eleuteri and Alessandro Mezzani and {Di Stefano}, Antonino and Davide Vallese and Isabella Gnemmi and {Delle Donne}, Lorena and Adriano Taddeo and {Della Bella}, Silvia and Pantaleo Giannuzzi",

year = "2013",

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doi = "10.3109/1354750X.2013.805342",

language = "English",

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AU - Eleuteri, Ermanno

AU - Mezzani, Alessandro

AU - Di Stefano, Antonino

AU - Vallese, Davide

AU - Gnemmi, Isabella

AU - Delle Donne, Lorena

AU - Taddeo, Adriano

AU - Della Bella, Silvia

AU - Giannuzzi, Pantaleo

PY - 2013/8

Y1 - 2013/8

N2 - The pathophysiology of chronic heart failure (CHF) involves multiple hystologic and molecular alterations. To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1α) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64+2 years, NYHA 2). At the end of the study, EPCs count and AP-2 serum levels significantly increased in the CHF-TR group. These preliminary data suggest a significant effect of even a short program of physical training on angiogenic activation and endothelial dysfunction.

AB - The pathophysiology of chronic heart failure (CHF) involves multiple hystologic and molecular alterations. To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1α) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64+2 years, NYHA 2). At the end of the study, EPCs count and AP-2 serum levels significantly increased in the CHF-TR group. These preliminary data suggest a significant effect of even a short program of physical training on angiogenic activation and endothelial dysfunction.

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KW - Growth factors/cytokines/inflammatory mediators

KW - Sports science/exercise

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Aerobic training and angiogenesis activation in patients with stable chronic heart failure: A preliminary report

Abstract

Keywords

ASJC Scopus subject areas

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