TY - JOUR
T1 - Aerobic exercise improves cardiac autonomic modulation in women with polycystic ovary syndrome
AU - Sá, Joceline C F
AU - Costa, Eduardo C.
AU - Da Silva, Ester
AU - Tamburús, Nayara Y.
AU - Porta, Alberto
AU - Medeiros, Leany F.
AU - Lemos, Telma M A M
AU - Soares, Elvira M M
AU - Azevedo, George D.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Background This study aimed to evaluate the effects of aerobic exercise on cardiac autonomic modulation in women with polycystic ovary syndrome (PCOS). Methods Thirty women with PCOS (25.8 ± 4.8 years old; body mass index, BMI ≥ 25 kg/m2) were divided into two groups; exercise group (n = 15) and control group (n = 15). R-R interval was recorded during 15-min at rest in the supine position. Heart rate variability (HRV) was analyzed by linear (rMSSD, SDNN, LF, HF, LFnu, HFnu, and LF/HF) and nonlinear methods (Shannon entropy, SE; symbolic analyses, 0 V%, 1 V%, 2LV%, and 2UV%) at baseline and after 16 weeks. The multivariate analysis of covariance was used to analyze the effects of exercise on HRV indexes, adjusted for changes in BMI, fasting insulin, and testosterone level. Results The exercise group increased parasympathetic modulation (rMSSD, HF, HFnu, 2UV%; (p <0.05)) and decreased sympathetic modulation (LF, LFnu, 0 V%; (p <0.05)) independently of changes in BMI, fasting insulin, and testosterone level. Moreover, the exercise group decreased resting HR and systolic blood pressure (p <0.05). All parameters remained unchanged in the control group. Conclusions Aerobic exercise increased vagal modulation and decreased sympathetic modulation in women with PCOS. This finding reinforces the recommendations for exercise during the clinical management of these patients.
AB - Background This study aimed to evaluate the effects of aerobic exercise on cardiac autonomic modulation in women with polycystic ovary syndrome (PCOS). Methods Thirty women with PCOS (25.8 ± 4.8 years old; body mass index, BMI ≥ 25 kg/m2) were divided into two groups; exercise group (n = 15) and control group (n = 15). R-R interval was recorded during 15-min at rest in the supine position. Heart rate variability (HRV) was analyzed by linear (rMSSD, SDNN, LF, HF, LFnu, HFnu, and LF/HF) and nonlinear methods (Shannon entropy, SE; symbolic analyses, 0 V%, 1 V%, 2LV%, and 2UV%) at baseline and after 16 weeks. The multivariate analysis of covariance was used to analyze the effects of exercise on HRV indexes, adjusted for changes in BMI, fasting insulin, and testosterone level. Results The exercise group increased parasympathetic modulation (rMSSD, HF, HFnu, 2UV%; (p <0.05)) and decreased sympathetic modulation (LF, LFnu, 0 V%; (p <0.05)) independently of changes in BMI, fasting insulin, and testosterone level. Moreover, the exercise group decreased resting HR and systolic blood pressure (p <0.05). All parameters remained unchanged in the control group. Conclusions Aerobic exercise increased vagal modulation and decreased sympathetic modulation in women with PCOS. This finding reinforces the recommendations for exercise during the clinical management of these patients.
KW - Aerobic exercise
KW - Autonomic nervous system
KW - Cardiac autonomic modulation
KW - Complexity
KW - Heart rate variability
KW - Polycystic ovary syndrome
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U2 - 10.1016/j.ijcard.2015.09.031
DO - 10.1016/j.ijcard.2015.09.031
M3 - Article
C2 - 26426277
AN - SCOPUS:84959433757
SN - 0167-5273
VL - 202
SP - 356
EP - 361
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -