Adult syncytial giant cell chronic hepatitis due to herbal remedy

Mirella Fraquelli, Agostino Colli, Massimo Cocciolo, Dario Conte

Research output: Contribution to journalArticlepeer-review


Syncytial giant cell hepatitis is an uncommon form of chronic hepatitis in adults, although it has been reported in association with viral infection (including HCV and HIV infection), drug reactions and autoimmune disorders. We here report a very unusual ease of giant cell chronic hepatitis in a 26-old-woman, who had been taking a herbal remedy (ISABGOL) for chronic constipation. The presence of viral and metabolic diseases has been excluded; an autoimmune etiology was very unlikely as the autoimmunity test remained negative during the year of follow-up and the total disease score normalized (from 13 to 8) without corticosteroid treatment. The causative role of the herbal remedy was further supported by the spontaneous and dramatic clinical, biochemical and histologic improvement observed following its withdrawal, despite the absence of any treatment.

Original languageEnglish
Pages (from-to)505-508
Number of pages4
JournalJournal of Hepatology
Issue number3
Publication statusPublished - 2000


  • Herbal remedy
  • Syncytial giant cell hepatitis

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Adult syncytial giant cell chronic hepatitis due to herbal remedy'. Together they form a unique fingerprint.

Cite this